14 August 2021 : Database Analysis
Identification of Mucus-Associated Molecular Subtypes of Chronic Obstructive Pulmonary Disease: A Latent Profile Analysis Based on MUC5B-Associated Genes
Yuanlong Hu1ACE, Xiaomeng Cheng1BCEF, Zhanjun Qiu2ADG*, Xianhai Chen2ADFGDOI: 10.12659/MSM.931222
Med Sci Monit 2021; 27:e931222
Supplementary Table 1 Clinical characteristics in the GSE47460-GPL14550 and GSE47460-GPL6480 dataset.
| Variable | GSE47460-GPL14550 | GSE47460-GPL6480 | ||||
|---|---|---|---|---|---|---|
| Control (N=91)* | COPD (N=145)* | p-value** | Control (N=17)* | COPD (N=75)* | p-value** | |
| Age (years) | 65 (58, 72) | 67 (60, 73) | 0.2 | 65 (56, 71) | 61 (56, 70) | >0.9 |
| Gender | 0.15 | 0.7 | ||||
| Female | 51 (56%) | 66 (46%) | 8 (47%) | 29 (39%) | ||
| Male | 40 (44%) | 79 (54%) | 9 (53%) | 46 (61%) | ||
| Smoke Status | ||||||
| Current | 1 (1.4%) | 11 (7.6%) | 0 (0%) | 3 (4.2%) | ||
| Ever | 49 (69%) | 125 (86%) | 9 (53%) | 66 (92%) | ||
| Never | 21 (30%) | 9 (6.2%) | 8 (47%) | 3 (4.2%) | ||
| Emphysema (%) | 0 (0, 1) | 7 (1, 24) | 0 (0, 1) | 9 (2, 36) | ||
| DLCO (%predicted) | 80 (72, 92) | 53 (39, 72) | 88 (84, 102) | 57 (34, 73) | ||
| FEV (pre-bd, %predicted) | 92 (85, 102) | 54 (33, 67) | 99 (91, 104) | 42 (24, 68) | ||
| FEV (post-bd, %predicted) | 95 (90, 104) | 58 (35, 71) | 102 (98, 110) | 59 (34, 76) | ||
| FVC (pre-bd, %predicted) | 92 (86, 102) | 76 (64, 88) | 95 (88, 102) | 71 (54, 82) | ||
| FVC (post-bd, %predicted) | 94 (88, 104) | 82 (71, 92) | 95 (94, 104) | 83 (66, 94) | 0.007 | |
| * Statistics presented: median (IQR); n (%); ** Statistical tests performed: Wilcoxon rank-sum test; Fisher’s exact test; chi-square test of independence. | ||||||