14 August 2021>: Database Analysis
Identification of Mucus-Associated Molecular Subtypes of Chronic Obstructive Pulmonary Disease: A Latent Profile Analysis Based on MUC5B-Associated Genes
Yuanlong Hu 1ACE* , Xiaomeng Cheng 1BCEF* , Zhanjun Qiu 2ADG* , Xianhai Chen 2ADFG*DOI: 10.12659/MSM.931222
Med Sci Monit 2021; 27:e931222
Supplementary Table 4 Differences in clinical characteristics among subtypes in the GSE47460-GPL6480 dataset.
Variable | Subtype1 (N=21)* | Subtype2 (N=29)* | Subtype3 (N=25)* | p-value** |
---|---|---|---|---|
Age (years) | 57 (52, 63) | 61 (57, 72) | 66 (56, 70) | 0.2 |
Gender | 0.3 | |||
Female | 10 (48%) | 19 (66%) | 17 (68%) | |
Male | 11 (52%) | 10 (34%) | 8 (32%) | |
Smoke status | 0.067 | |||
Current | 0 (0%) | 0 (0%) | 3 (12%) | |
Ever | 21 (100%) | 26 (96%) | 19 (79%) | |
Never | 0 (0%) | 1 (3.7%) | 2 (8.3%) | |
Emphysema (%)# | 27 (2, 45) | 14 (6, 39) | 4 (1, 16) | 0.081 |
DLCO (%predicted) | 56 (32, 70) | 54 (34, 74) | 64 (41, 71) | 0.9 |
FEV (pre-bd, %predicted)## | 26 (18, 57) | 40 (24, 70) | 52 (35, 64) | 0.2 |
FEV (post-bd, %predicted)## | 58 (28, 77) | 58 (28, 78) | 59 (43, 73) | >0.9 |
FVC (pre-bd, %predicted)## | 68 (51, 77) | 73 (63, 85) | 74 (55, 81) | 0.4 |
FVC (post-bd, %predicted)## | 90 (68, 97) | 84 (76, 99) | 78 (64, 88) | 0.3 |
* Statistics presented: median (IQR); n (%); ** statistical tests performed: Wilcoxon rank-sum test; Fisher’s exact test; chi-square test of independence; # emphysema(%) was defined as percent of lung attenuation voxels below −950 Hounsfield units (HU); ## BD refers to bronchodilator. |