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25 December 2021: Clinical Research

Association of Perioperative Myocardial Injury with 30-Day and Long-Term Mortality in Older Adult Patients Undergoing Orthopedic Surgery in China

Wenlan Hu 1BCDE , Youzhou Chen 1BCD , Kaiping Zhao 2BCD , Jihong Wang 1BCD , Mei Zheng 1BCD , Ying Zhao 1BCD , Hao Han 1BCD , Qiong Zhao 3AE* , Xingshan Zhao 1AE*

DOI: 10.12659/MSM.932036

Med Sci Monit 2021; 27:e932036

STROBE Statement – checklist of items that should be included in reports of observational studies.

Item NoRecommendation
1() Indicate the study’s design with a commonly used term in the title or the abstract
() Provide in the abstract an informative and balanced summary of what was done and what was found
Background √2Explain the scientific background and rationale for the investigation being reported
Objectives √3State specific objectives, including any prespecified hypotheses
Study design √4Present key elements of study design early in the paper
Setting √5Describe the setting, locations, and relevant dates, including periods of recruitment, exposure, follow-up, and data collection
Participants √6() – Give the eligibility criteria, and the sources and methods of selection of participants. Describe methods of follow-up – Give the eligibility criteria, and the sources and methods of case ascertainment and control selection. Give the rationale for the choice of cases and controls – Give the eligibility criteria, and the sources and methods of selection of participants
() – For matched studies, give matching criteria and number of exposed and unexposed – For matched studies, give matching criteria and the number of controls per case
Variables √7Clearly define all outcomes, exposures, predictors, potential confounders, and effect modifiers. Give diagnostic criteria, if applicable
Data sources/measurement √8* For each variable of interest, give sources of data and details of methods of assessment (measurement). Describe comparability of assessment methods if there is more than one group
Bias √9Describe any efforts to address potential sources of bias
Study size √10Explain how the study size was arrived at
Quantitative variables √11Explain how quantitative variables were handled in the analyses. If applicable, describe which groupings were chosen and why
Statistical methods √12() Describe all statistical methods, including those used to control for confounding
() Describe any methods used to examine subgroups and interactions
() Explain how missing data were addressed
() – If applicable, explain how loss to follow-up was addressed – If applicable, explain how matching of cases and controls was addressed – If applicable, describe analytical methods taking account of sampling strategy
() Describe any sensitivity analyses
ParticipantsN/A13* () Report numbers of individuals at each stage of study – eg numbers potentially eligible, examined for eligibility, confirmed eligible, included in the study, completing follow-up, and analysed
() Give reasons for non-participation at each stage
() Consider use of a flow diagram
Descriptive data √14* () Give characteristics of study participants (eg demographic, clinical, social) and information on exposures and potential confounders
() Indicate number of participants with missing data for each variable of interest
() – Summarise follow-up time (eg, average and total amount)
Outcome data √15* – Report numbers of outcome events or summary measures over time
– Report numbers in each exposure category, or summary measures of exposure
– Report numbers of outcome events or summary measures
Main results √16() Give unadjusted estimates and, if applicable, confounder-adjusted estimates and their precision (eg, 95% confidence interval). Make clear which confounders were adjusted for and why they were included
() Report category boundaries when continuous variables were categorized
() If relevant, consider translating estimates of relative risk into absolute risk for a meaningful time period
Other analysesN/A17Report other analyses done – eg analyses of subgroups and interactions, and sensitivity analyses
Key results √18Summarise key results with reference to study objectives
Limitations √19Discuss limitations of the study, taking into account sources of potential bias or imprecision. Discuss both direction and magnitude of any potential bias
Interpretation √20Give a cautious overall interpretation of results considering objectives, limitations, multiplicity of analyses, results from similar studies, and other relevant evidence
GeneralisabilityN/ADiscuss the generalisability (external validity) of the study results
Other information
FundingN/A22Give the source of funding and the role of the funders for the present study and, if applicable, for the original study on which the present article is based
Continued on next page
* Give information separately for cases and controls in case-control studies and, if applicable, for exposed and unexposed groups in cohort and cross-sectional studies.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750