24 November 2021 : Clinical Research
Discoidin Domain Receptor Tyrosine Kinase 1 (DDR1): A Novel Predictor for Recurrence of Hepatocellular Carcinoma After Curative Resection
Meng Xu1CDEFG, Chenghao Cui1AB*DOI: 10.12659/MSM.933109
Med Sci Monit 2021; 27:e933109
Table 2 Correlation between DDR1 and clinicopathologic characteristics.
Clinical Characteristic | Patients Number | DDR1 in serum | P | DDR1 in tumor | P | ||
---|---|---|---|---|---|---|---|
Low | High | Low | High | ||||
Age | |||||||
≤50 | 54 | 21 | 33 | 0.713 | 19 | 35 | 1.000 |
>50 | 66 | 28 | 38 | 23 | 43 | ||
Sex | |||||||
Male | 31 | 10 | 21 | 0.295 | 10 | 21 | 0.808 |
Female | 89 | 39 | 50 | 32 | 57 | ||
AFP | |||||||
≤400 ng/mL | 93 | 37 | 56 | 0.664 | 31 | 62 | 0.499 |
>400 ng/mL | 27 | 12 | 15 | 11 | 16 | ||
ALT | |||||||
≤75 U/L | 79 | 34 | 45 | 0.700 | 26 | 52 | 0.689 |
>75 U/L | 42 | 16 | 26 | 16 | 26 | ||
Tumor size | |||||||
≤5 cm | 67 | 30 | 37 | 0.354 | 23 | 44 | 1.000 |
>5 cm | 53 | 19 | 34 | 18 | 34 | ||
Tumor number | |||||||
Single | 103 | 41 | 62 | 0.603 | 37 | 66 | 0.785 |
Multiple | 17 | 8 | 9 | 5 | 12 | ||
HbsAg | |||||||
Negative | 18 | 6 | 12 | 0.606 | 8 | 10 | 0.425 |
Positive | 102 | 43 | 59 | 34 | 68 | ||
Liver cirrhosis | |||||||
No | 22 | 10 | 12 | 0.639 | 10 | 12 | 0.323 |
Yes | 98 | 39 | 59 | 32 | 66 | ||
Microvascular invasion | |||||||
No | 46 | 25 | 21 | 23 | 23 | ||
Yes | 74 | 24 | 50 | 19 | 55 | ||
CTC | |||||||
≤2/5 ml | 61 | 31 | 30 | 30 | 31 | ||
>2/5 ml | 59 | 18 | 41 | 12 | 47 | ||
Encapsulation | |||||||
Complete | 81 | 32 | 49 | 0.696 | 24 | 57 | 0.102 |
Incomplete | 39 | 17 | 22 | 18 | 21 | ||
Satellite lesion | |||||||
No | 104 | 40 | 64 | 0.274 | 34 | 70 | 0.259 |
Yes | 16 | 8 | 8 | 8 | 8 | ||
Child-Pugh score | |||||||
A | 111 | 46 | 65 | 0.736 | 34 | 74 | 0.274 |
B | 9 | 3 | 6 | 5 | 4 | ||
Edmondson stage | |||||||
I–II | 73 | 31 | 42 | 0.664 | 23 | 50 | 0.334 |
III–IV | 47 | 18 | 29 | 19 | 28 | ||
BCLC Stage | |||||||
0-A | 94 | 36 | 58 | 0.368 | 33 | 61 | 1.000 |
B-D | 26 | 13 | 13 | 9 | 17 |