24 November 2021 : Clinical Research
Discoidin Domain Receptor Tyrosine Kinase 1 (DDR1): A Novel Predictor for Recurrence of Hepatocellular Carcinoma After Curative Resection
Meng Xu1CDEFG, Chenghao Cui1AB*DOI: 10.12659/MSM.933109
Med Sci Monit 2021; 27:e933109
Table 3 Univariate and multivariate Cox regression analysis of factors associated with recurrence.
Variables | Univariate analysis | Multivariate analysis | |||
---|---|---|---|---|---|
HR | P | HR | P | ||
Age | >50 vs ≤50 | 0.889 (0.551–1.434) | 0.629 | NA | NA |
Gender | Male vs Female | 1.076 (0.626–1.847) | 0.791 | NA | NA |
AFP | >400 ng/mL vs ≤400 ng/mL | 1.774 (1.100–2.862) | 1.568 (0.945–2.603) | 0.082 | |
ALT | >75 U/L vs ≤75 U/L | 0.969 (0.586–1.602) | 0.902 | NA | NA |
Tumor size | >5 cm vs ≤5 cm | 1.783 (1.092–2.912) | 1.375 (0.958–2.686) | 0.073 | |
Tumor number | Multiple vs single | 3.426 (2.090–5.615) | 2.855 (1.686–4.836) | ||
HbsAg | Positive vs negative | 2.167 (0.989–4.747) | 0.053 | NA | NA |
Liver cirrhosis | Yes vs no | 1.378 (0.669–2.681) | 0.361 | NA | NA |
Encapsulation | Incomplete vs complete | 1.115 (0.670–1.875) | 0.675 | NA | NA |
Satellite lesion | Yes vs no | 0.601 (0.274–1.315) | 0.202 | NA | NA |
Child-Pugh score | B vs A | 1.505 (0.678–3.296) | 0.307 | NA | NA |
Edmondson stage | III–IV vs I–II | 1.489 (0.920–2.408) | 0.105 | NA | NA |
BCLC Stage | B-D vs 0-A | 1.230 (0.708–2.137) | 0.463 | NA | NA |
DDR1 in serum | High vs low | 1.902 (1.150–3.146) | 1.520 (1.078–2. 640) | ||
DDR1 in tumor | High vs low | 2.199 (1.275–3.790) | 1.811 (1.117–3.241) |