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31 January 2022: Meta-Analysis

Utility of Pretreatment Blood Platelet-To-Lymphocyte Ratio in Prediction of Clinical Outcomes and Chemosensitivity in Patients with Advanced Gastric Cancer: A Meta-Analysis

Xiulan Peng 1AE* , Wei Zeng 2BF* , Bing Tang 3CF* , Anbing He 1B , Min Zhang 1B , Renfeng Luo 4AB*

DOI: 10.12659/MSM.933449

Med Sci Monit 2022; 28:e933449

Table 2 Subgroup analyses of pooled HRs and 95% CIs for OS based on different factors.

Subgroup analysisNo. of studiesNo. of patientsEffects modelHR (95% CI)P valueHeterogeneity
I2 (%)p value
NOS score
 >792190Random1.36 (1.08–1.72)0.01070.80.001
 ≤77963Fixed1.46 (1.29–1.65)16.10.303
Sample size
 ≥16882453Fixed1.53 (1.37–1.70)15.50.308
8700Random1.37 (1.05–1.80)0.02064.10.007
 Chemotherapy102090Random1.34 (1.11–1.62)0.00263.70.003
 Mixed61063Fixed1.62 (1.39–1.89)0.00.646
Cut-off value
 ≥16191836Fixed1.37 (1.22–1.53)37.30.120
71317Random1.41 (1.11–1.80)0.00568.60.004
Cut-off method
 ROC curve81687Fixed1.48 (1.29–1.71)41.70.100
 Median4787Random1.22 (0.88–1.70)0.23878.00.003
 NA3375Fixed1.62 (1.34–1.95)0.00.774
 X-title13041.59 (1.02–2.48)0.041
 Caucasian3369Random1.30 (0.71–2.39)0.39487.8
 Asian132784Fixed1.43 (1.30–1.58)25.10.190
 Total163153Random1.43 (1.25–1.64)54.10.005
CI – confidence interval; HR – hazard ratio; OS – overall survival; DFS – disease-free survival; ROC – receiver operating characteristics curve; PLR – platelet to lymphocyte ratio (I >50% or

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750