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31 January 2022: Meta-Analysis

Utility of Pretreatment Blood Platelet-To-Lymphocyte Ratio in Prediction of Clinical Outcomes and Chemosensitivity in Patients with Advanced Gastric Cancer: A Meta-Analysis

Xiulan Peng 1AE* , Wei Zeng 2BF* , Bing Tang 3CF* , Anbing He 1B , Min Zhang 1B , Renfeng Luo 4AB*

DOI: 10.12659/MSM.933449

Med Sci Monit 2022; 28:e933449

Table 3 Correlations of PLR and clinicopathological characteristics in patients with advanced GC.

Clinicopathological featuresNo. of studiesNo. of patientsEffects modelOR (95% CI)P valueHeterogeneity
I2 (%)p value
ECOG (≥2 versus4567Random1.36 (0.49–3.73)0.55753.10.094
Tumor size (≥5 cm versus3557Random1.13 (0.57–2.25)0.72985.60.001
Sex (Male versus Female)121989Random0.94 (0.79–1.11)0.46884.2
Age (years) (≥60 versus41077Random1.40 (0.83–2.36)0.21194.5
Tumor differentiation (poor versus moderate/well)71428Fixed0.99 (0.90–1.08)0.7340.00.454
CEA leve (≥5 versus51129Fixed1.13 (0.97–1.32)0.1310.00.635
CI – confidence interval; OR – odds ratio; PLR – platelet-to-lymphocyte ratio; GC – gastric cancer; ECOG – Eastern Cooperative Oncology Group, CEA – carcino-embryonic antigen.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750