31 January 2022 : Meta-Analysis
Utility of Pretreatment Blood Platelet-To-Lymphocyte Ratio in Prediction of Clinical Outcomes and Chemosensitivity in Patients with Advanced Gastric Cancer: A Meta-Analysis
Xiulan Peng1AE*, Wei Zeng2BF, Bing Tang3CF, Anbing He1B, Min Zhang1B, Renfeng Luo4ABDOI: 10.12659/MSM.933449
Med Sci Monit 2022; 28:e933449
Table 3 Correlations of PLR and clinicopathological characteristics in patients with advanced GC.
| Clinicopathological features | No. of studies | No. of patients | Effects model | OR (95% CI) | P value | Heterogeneity | |
|---|---|---|---|---|---|---|---|
| I2 (%) | p value | ||||||
| ECOG (≥2 versus <2) | 4 | 567 | Random | 1.36 (0.49–3.73) | 0.557 | 53.1 | 0.094 |
| Tumor size (≥5 cm versus <5 cm) | 3 | 557 | Random | 1.13 (0.57–2.25) | 0.729 | 85.6 | 0.001 |
| Sex (Male versus Female) | 12 | 1989 | Random | 0.94 (0.79–1.11) | 0.468 | 84.2 | <0.001 |
| Age (years) (≥60 versus <60) | 4 | 1077 | Random | 1.40 (0.83–2.36) | 0.211 | 94.5 | <0.001 |
| Tumor differentiation (poor versus moderate/well) | 7 | 1428 | Fixed | 0.99 (0.90–1.08) | 0.734 | 0.0 | 0.454 |
| CEA leve (≥5 versus <5) | 5 | 1129 | Fixed | 1.13 (0.97–1.32) | 0.131 | 0.0 | 0.635 |
| CI – confidence interval; OR – odds ratio; PLR – platelet-to-lymphocyte ratio; GC – gastric cancer; ECOG – Eastern Cooperative Oncology Group, CEA – carcino-embryonic antigen. | |||||||