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10 October 2021: Animal Study

Pretreatment with Methylene Blue Protects Against Acute Seizure and Oxidative Stress in a Kainic Acid-Induced Status Epilepticus Model

Yong-feng Wang 1E* , Yan Luo 2C* , Gao-lei Hou 1B , Rui-jing He 3C , Hao-yun Zhang 3F , Yan-Li Yi 3D , Ying Zhang 3B , Zhi-qiang Cui 3AG*

DOI: 10.12659/MSM.933469

Med Sci Monit 2021; 27:e933469

Table 1 Effect of MB on KA-induced acute seizure onset in mice. Data are mean ± SEM for latency to different seizure phase.

GroupLatent time (min)Percentage of incidence of SE (%)Survival percentage (%)
Phase 1–3Phase 4–5Phase SE
MB 0.5 mg/Kg+KA9.9±0.4927.4±1.14* 112.1±5.35* 17* 100
MB 1 mg/Kg+KA10.7±0.6130.4±1.11* 117.3±2.67* 8* 100
* P

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750