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27 February 2022: Clinical Research

Serum Uric Acid Levels in Relation to Atrial Fibrillation: A Case-Control Study

Xia Zhong 1ABCDEF , Huachen Jiao 2ABCFG* , Dongsheng Zhao 1BD , Jing Teng 1CF

DOI: 10.12659/MSM.934007

Med Sci Monit 2022; 28:e934007

Table 1 Demographic and clinical characteristics of control and atrial fibrillation group.

VariableControl group (n=492)AF group (n=478)P value
SUA, mg/dL5.35±1.555.66±1.900.006
Male, mg/dL6.05±1.566.15±1.990.385
Female, mg/dL4.58±1.215.33±1.88
Hyperuricemia102 (20.7)142 (20.7)0.001
Male, n (%)66 (64.7)70 (49.3)0.017
Female, n (%)36 (35.3)72 (50.7)
Age, years64.69±15.7264.87±10.750.835
Male, n (%)266 (54.1)253 (52.9)0.723
Hypertension, n (%)172 (35.0)315 (65.9)
Diabetes, n (%)82 (16.7)135 (28.2)
CHD, n (%)146 (29.7)443 (72.7)
Scr, μmoI/L66.95±34.4378.23±55.15
FBG, mmol/L5.97±1.806.10±1.970.284
ALT, U/L17 (12–25)16 (12–24)0.424
AST, U/L18 (15–23)19.5 (16–25)0.001
ALT/AST1.15±0.511.28±0.55
APOA1, g/L1.22±0.251.08±0.25
APOB, g/L1.00±0.250.81±0.48
ALB, g/L40.30±4.0437.75±4.59
Ig, g/L28.10±3.9928.48±4.350.156
A/G1.46±0.221.35±0.24
PAB, mg/L227.69±52.68190.63±60.78
Lp (a), mg/L14 (6.3–27.9)14.5 (7.85–28.78)0.160
β-blockers, n (%)109 (22.2)367 (76.8)
CCBs, n (%)102 (20.7)162 (33.9)
ACEI/ARB, n (%)104 (21.1)284 (59.4)
Statins, n (%)128 (26.0)308 (64.4)
Data are presented as mean±standard deviation (SD), median (interquartile range [IQR]), or n (%). AF – atrial fibrillation; CHD – coronary heart disease; Scr – serum creatinine; FBG – fasting blood glucose; ALT – alanine aminotransferase; AST – aspartate aminotransferase; AST/ALT – aspartate aminotransferase/alanine aminotransferase; APOA1 – serum apolipoprotein A1; APOB – serum apolipoprotein B; ALB – albumin; Ig – immunoglobulin; A/G – albumin/globulin; PAB – prealbumin; Lp (a) – lipoprotein (a); CCBs – calcium channel blockers; ACEI/ARB – angiotensin-converting enzyme inhibitor/angiotensin receptor blocker.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750