15 January 2022 : Database Analysis
Prediction of Patient Survival with Psoas Muscle Density Following Transjugular Intrahepatic Portosystemic Shunts: A Retrospective Cohort Study
Biyu Zhang1ABCDEF, Weimin Cai1ABCDEF, Feng Gao1BE, Xinran Lin1BC, Ting Qian1F, Kaier Gu1B, Bingxin Song1B, Tanzhou Chen1A*DOI: 10.12659/MSM.934057
Med Sci Monit 2022; 28:e934057
Table 3 Characteristics of the study population, stratified by PMD measurement.a
| Variables | All patients n=273 | Low PMD n=102 | High PMD n=171 | P valueb |
|---|---|---|---|---|
| Basic information | ||||
| Survival | 242 | 79 | 163 | <0.001 |
| Age, y | 53.54±10.51 | 58.68±8.10 | 50.47±10.61 | <0.001 |
| Sex | ||||
| Male | 194 | 61 | 133 | 0.002 |
| Female | 79 | 41 | 38 | |
| BMI | 22.87±3.15 | 24.08±3.49 | 22.29±2.83 | 0.016 |
| Hypertension | 27 | 17 | 10 | 0.004 |
| Smoking | 105 | 33 | 72 | 0.109 |
| Splenectomy | 22 | 9 | 13 | 0.720 |
| Etiology of cirrhosis | 0.217 | |||
| Alcoholic | 53 | 23 | 30 | |
| Viral (HBV or HCV) | 151 | 50 | 101 | |
| Both alcohol and viral | 35 | 12 | 23 | |
| Othersc | 34 | 17 | 17 | |
| Reasons for TIPS | 0.099 | |||
| EGVB | 246 | 87 | 159 | |
| RF | 13 | 8 | 5 | |
| Othersd | 14 | 7 | 7 | |
| TIPS targeted puncture | 0.007 | |||
| Left branch of the intrahepatic portal vein | 199 | 66 | 133 | |
| Right branch of the intrahepatic portal vein | 61 | 30 | 31 | |
| Otherse | 13 | 6 | 7 | |
| Stent-graft diameters, mm | 8 (8–9) | 8 (8–10) | 8 (8–9) | 0.002 |
| RBC, ×10 | 3.02±0.71 | 2.86±0.68 | 3.11±0.72 | 0.006 |
| WBC, ×10 | 5.06±3.59 | 5.22±4.00 | 4.96±3.33 | 0.566 |
| Lymphocyte, ×10 | 0.99±0.87 | 0.95±0.61 | 1.01±1.01 | 0.580 |
| Neutrophil, ×10 | 3.34±2.68 | 3.50±2.97 | 3.24±2.49 | 0.447 |
| Platelet, ×10 | 81.42±61.95 | 86.23±63.57 | 78.56±60.97 | 0.324 |
| Hemoglobin, g/L | 85.78±24.74 | 83.50±21.44 | 87.13±26.49 | 0.241 |
| Albumin, g/L | 30.18±5.39 | 28.97±5.98 | 30.89±4.88 | 0.004 |
| Total bilirubin, μmol/L | 24.30±17.60 | 25.93±17.90 | 23.33±17.40 | 0.239 |
| ALT, U/L | 43.02±106.98 | 40.66±75.20 | 44.43±122.25 | 0.778 |
| AST, U/L | 55.24±100.32 | 56.39±63.21 | 54.55±117.16 | 0.884 |
| Serum creatinine, μmol/L | 66.15±17.06 | 66.22±30.95 | 66.11±17.60 | 0.970 |
| Serum sodium, mmol/L | 137.44±4.37 | 137.22±4.66 | 137.56±4.21 | 0.526 |
| Prothrombin time, s | 17.34±2.67 | 17.72±3.52 | 17.11±1.98 | 0.067 |
| INR | 1.42±0.24 | 1.42±0.25 | 1.42±0.23 | 0.986 |
| Child-Pugh score | 7 (6–9) | 7 (6–9) | 9 (8–10) | <0.001 |
| MELD score | 11.45 (9.76–13.46) | 11.69 (9.59–14.02) | 11.18 (9.82–13.20) | 0.224 |
| MELD-Na score | 10.91 (7.47–14.50) | 12.22 (7.31–15.27) | 10.62 (7.44–14.07) | 0.207 |
| ALT – alanine aminotransferase; AST – aspartate aminotransferase; BMI – body mass index; EGVB – esophageal gastric-fundus variceal bleeding; HBV – hepatitis B virus; HCV – hepatitis C virus; HU – Hounsfield units; INR – international standardization ratio; MELD – model for end-stage liver disease; MELD-Na – composite index of model for end-stage liver disease and serum sodium; PMD – psoas muscle density; RBC – red blood cell count; RF – refractory ascites; TIPS – transjugular intrahepatic portosystemic shunt; WBC – white blood cell count. a Descriptive statistics are expressed as numbers or mean values (±SD), as appropriate. Continuous variables are expressed as means±SD or medians with interquartile ranges. b The test or the Mann-Whitney U test was used to compare 2 groups, and χ test or Fisher exact test was used to compare categorical variables. c Others included primary biliary cirrhosis, autoimmune diseases, Budd-Chiari syndrome, and cryptogenic cirrhosis. d Others included preventive therapy, portal system thrombosis, and alleviation of abdominal discomfort. e Others included portal vein trunk, right branches of the portal vein, and confluence of the left branches of the portal vein. | ||||