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25 February 2022: Review Articles

A Review of Circulating Tumor DNA in the Diagnosis and Monitoring of Esophageal Cancer

Min Jiang 1EF , Huilin Zhou 1F , Su Jiang 2F , Hong Yu 1AEG*

DOI: 10.12659/MSM.934106

Med Sci Monit 2022; 28:e934106

Table 1 Summary of studies involving circulating tumor DNA (ctDNA) and esophageal cancer.

StudiesMethodsNo. of patientsNo. of sampleSample typesPurpose
[]72 NGS45213Tissues and plasmaDetection of minimal residual disease
[]18 NGS2121PlasmaDiagnosis
[]64 NGS3030Tissues and plasmaPredicting treatment outcomes
[106]NGS5656Tissues and plasmaDetermining the feasibility of ctDNA assay in advanced gastrointestinal and anal cancers
[107]NGS88PlasmaDetermining the feasibility of ctDNA assay in advanced gastrointestinal cancers
[]88 qPCR4175PlasmaDiagnosis and surveillance
[]61 NGS35116Tissues and plasmaSurveillance
[]62 NGS, ddPCR42121Tissues and plasmaPredicting response to chemotherapy
[108]DNA quantification57143PlasmaMonitoring of treatment responses and relapse in advanced ESCC
[]66 NGS85449Tissues and plasmaDiagnosis
[]85 NGS20>60Tissues and plasmaSurveillance
[]58 NGS552Tissues and plasmaAnalyzing the concordance of somatic variants in ESCC tissues and ctDNA
[]56 NGS, Array-CGH4488Tissues and plasmaAnalyzing the concordance of copy number alterations in gastroesophageal cancer tissues and ctDNA
[109]NGS716689PlasmaDiagnosis
[]67 NGS1004077PlasmaDiagnosis
[]34 NGS320Tissues and plasmaPredicting response to neoadjuvant therapy
[]71 NGS, ddPCR35604Tissues and plasmaMonitoring clinical outcome during the treatment course of ESCC patients
[]46 NGS97245PlasmaSurveillance
[]86 NGS2569PlasmaMonitoring the prognosis of ESCC patients receiving radiotherapy
[]82 NGS150227PlasmaDiagnosis
[]57 NGS4281Tissues and plasmaAnalyzing the concordance of TP53 mutations in ESCC tissues and ctDNA
[110]NGS, ddPCR27>52Tissues and plasmaDetermining the feasibility of ctDNA assay in esophageal cancer
[]73 LOH analysis4040PlasmaMonitoring the neoplastic progression of Barrett’s esophagus
[]65 NGS61139PlasmaPredicting treatment outcomes
[]83 NGS1155Tissues and plasmaDetermining the feasibility of ctDNA assay in esophageal cancer
[]60 NGS1346Tissues and plasmaPredicting recurrence
[]59 NGS16302140Tissues and plasmaEvaluate the role of ctDNA in guiding clinical decision-making in gastroesophageal adenocarcinoma
[]45 NGS, ddPCR114Tissues and plasmaFalse-positive plasma genotyping
[]87 qPCR63115Tissues and plasmaPredicting recurrence
cfDNA – cell-free DNA; ctDNA – circulating tumor DNA; ddPCR – droplet digital polymerase chain reaction; ESCC – esophageal squamous cell carcinoma; LOH – loss of heterozygosity; qPCR – real-time fluorescence quantitative PCR; TP53 – tumor protein p53.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750