09 February 2022: Clinical Research
A Risk Prediction Model for Prolonged Length of Stay in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Retrospective Study of 225 Patients in a Single Center in Kunming, China
Lifen Yang 1ABCDEFG* , Meihua Li 1BCD , Jingkui Shu 2BCD , Yanxia Yang 1BCD , Qian Huang 3BCDDOI: 10.12659/MSM.934392
Med Sci Monit 2022; 28:e934392
Table 2 Differences in characteristics on the fourth day of hospitalization.
| Variable | Total (n=225) | Group | Statistic | P | |
|---|---|---|---|---|---|
| LOS≤7 days (n=73) | LOS >7 days (n=152) | ||||
| Blood routine examination | |||||
| WBC (10/L), mean±SD | 6.60±2.09 | 6.56±2.05 | 6.62±2.12 | t=0.19 | 0.853 |
| RBC (10/L), mean±SD | 4.80±0.81 | 4.77±0.81 | 4.81±0.81 | t=0.30 | 0.765 |
| PCV, mean±SD | 0.45±0.07 | 0.45±0.07 | 0.45±0.07 | t=−0.16 | 0.877 |
| Hb (g/L), mean±SD | 147.81±23.52 | 148.05±22.61 | 147.69±24.01 | t=−0.11 | 0.914 |
| PLT (10/L), M(Q, Q) | 181.00 (142.00, 220.00) | 174.00 (136.00, 216.00) | 185.50 (142.50, 228.00) | Z=−0.919 | 0.358 |
| NEUT (10/L), M(Q, Q) | 4.25 (3.21, 5.36) | 4.25 (3.10, 5.35) | 4.25 (3.22, 5.36) | Z=−0.413 | 0.679 |
| LY (10/L), M(Q, Q) | 1.50 (1.10, 1.90) | 1.50 (1.10, 2.00) | 1.40 (1.10, 1.90) | Z=0.973 | 0.331 |
| Blood gas analysis | |||||
| pH, Mean±SD | 7.43±0.05 | 7.43±0.04 | 7.42±0.05 | t=−1.06 | 0.292 |
| PaCO (mmHg), Mean±SD | 42.39±10.97 | 40.47±11.55 | 43.30±10.59 | t=1.82 | 0.070 |
| PaO/FiO (mmHg), M(Q, Q) | 265.00 (228.00, 310.00) | 255.00 (215.00, 290.00) | 269.50 (238.00, 320.50) | Z=−2.600 | 0.009 |
| HCO (mmol/L), Mean±SD | 27.95±5.19 | 26.92±5.67 | 28.45±4.88 | t=2.10 | 0.037 |
| BE (mmol/L), M(Q, Q) | 2.70 (1.00, 5.40) | 1.70 (0.20, 4.40) | 3.00 (1.25, 5.70) | Z=−2.112 | 0.035 |
| Infection markers test, M(Q, Q) | |||||
| CRP (mg/L) | 5.72 (2.00, 12.56) | 4.37 (2.00, 11.70) | 6.59 (2.00, 12.95) | Z=−0.728 | 0.467 |
| PCT (μg/L) | 0.05 (0.03, 0.07) | 0.05 (0.03, 0.07) | 0.05 (0.03, 0.08) | Z=−0.233 | 0.816 |
| Amyloid (mg/L) | 10.70 (4.31, 23.60) | 9.88 (4.09, 19.50) | 10.90 (5.03, 25.85) | Z=−1.084 | 0.278 |
| IL-6 (pg/mL) | 6.50 (3.50, 11.90) | 6.30 (3.40, 10.60) | 7.25 (3.55, 12.65) | Z=−0.583 | 0.560 |
| Medication during hospitalization, n(%) | |||||
| Corticosteroids | 89 (39.56) | 16 (21.92) | 73 (48.03) | χ=14.060 | |
| Antibiotics | 211 (93.78) | 66 (90.41) | 145 (95.39) | – | 0.154 |
| LOS – length of stay; WBC – white blood cell; RBC – red blood cell; PCV – packed-cell volume; Hb – hemoglobin; PLT – platelet; NEUT – neutrophil; LY – lymphocyte; PaCO – partial arterial carbon dioxide pressure; PaO/FiO – the ratio of partial arterial oxygen pressure to the fraction of inspired oxygen; BE – base excess; CRP – C-reactive protein; PCT – procalcitonin; SD – standard deviation; M(Q, Q) – median and quartile; n(%) – the number of cases and the constituent ratio; -: using Fisher’s test. | |||||