13 February 2022 : Clinical Research
Gas Chromatography and Flame-Ionization Detection of Non-Cholesterol Sterols as Indicators of Cholesterol Absorption and Synthesis in 158 Chinese Individuals with Normolipidemia, Hyperlipidemia, and Familial Hypercholesterolemia
Zhi-Zhao Li1DE*, Qi-Hui Wang2C, Yang Liu2C, lvya Wang3A, Zhen-Qiu Yu3A, Qiong Huang4B, Jing Zhang5BDOI: 10.12659/MSM.934471
Med Sci Monit 2022; 28:e934471
Table 1 Levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, total cholesterol, and fasting plasma glucose and blood pressure in healthy group and dyslipidemia and familial hypercholesterolemia groups.
| Item | Healthy group (n=64) | Dyslipidemia group (n=69) | FH group (n=25) | F/z | P |
|---|---|---|---|---|---|
| Age | 51.0 (45.0, 55.0) | 52.0±5.8 | 6–53 | −0.043 | 0.966 |
| Sex (male/female) | 16/48 | 30/39 | 13/12 | 7.573 | 0.023 |
| BMI | 24.33 (21.66, 27.69) | 26.01±3.58 | – | −1.84 | 0.066 |
| HDL-C (mmol/L) | 1.42 (1.30, 1.65) | 1.31 (1.13, 1.60) | 62.37±32.65 | 241.69 | <0.001 |
| LDL-C (mmol/L) | 3.03±0.53 | 3.38 (3.10, 4.09) | 553.70±167.18 | 756.54 | <0.001 |
| TG (mmol/L) | 1.20 (0.80–1.40) | 2.10 (1.60, 3.50) | 108.41±116.50 | 683.37 | <0.001 |
| TC (mmol/L) | 4.75±0.65 | 5.35 (4.89, 6.15) | 650.86±179.02 | 908.11 | <0.001 |
| FPG (mmol/L) | 5.00 (4.76, 5.36) | 5.40 (4.93, 6.00) | – | −3.487 | <0.001 |
| SBP (mm Hg) | 120.0 (110.0, 120.0) | 120.0 (110.0, 130.0) | – | −1.766 | 0.077 |
| DBP (mm Hg) | 80.0 (70.0, 80.0) | 80.0 (70.0, 90.0) | – | −1.258 | 0.208 |
| HDL-C – high-density lipoprotein cholesterol; LDL-C – low-density lipoprotein cholesterol; TG – triglycerides; TC – total cholesterol; FPG – fasting plasma glucose; SBP – systolic blood pressure; DBP – diastolic blood pressure; FH – familial hypercholesterolemia. | |||||