Gas Chromatography and Flame-Ionization Detection of Non-Cholesterol Sterols as Indicators of Cholesterol Absorption and Synthesis in 158 Chinese Individuals with Normolipidemia, Hyperlipidemia, and Familial Hypercholesterolemia

Zhi-Zhao Li; Qi-Hui Wang; Yang Liu; lvya Wang; Zhen-Qiu Yu; Qiong Huang; Jing Zhang

doi:10.12659/MSM.934471

13 February 2022 : Clinical Research

Gas Chromatography and Flame-Ionization Detection of Non-Cholesterol Sterols as Indicators of Cholesterol Absorption and Synthesis in 158 Chinese Individuals with Normolipidemia, Hyperlipidemia, and Familial Hypercholesterolemia

Zhi-Zhao Li^1DE*, Qi-Hui Wang^2C, Yang Liu^2C, lvya Wang^3A, Zhen-Qiu Yu^3A, Qiong Huang^4B, Jing Zhang^5B

DOI: 10.12659/MSM.934471

Med Sci Monit 2022; 28:e934471

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Table 2 Concentration and ratio of cholesterol synthesis and absorption markers to cholesterol in healthy group and dyslipidemia and familial hypercholesterolemia groups.

Sterols	Concentration (mg/dL)
Sterols	Healthy group (n=64)	Dyslipidemia group (n=69)	FH group (n=25)	F	P
Squalene	0.121 (0.099, 0.152)	0.160 (0.113, 0.254)	0.207 (0.119, 0.583)	0.075	0.928
Desmosterol	0.024±0.007	0.029±0.008	0.322±0.150	260.252	<0.001
Lathosterol	0.207 (0.159, 0.256)	0.322±0.126	0.653±0.416	46.503	<0.001
Campesterol	0.212 (0.156, 0.317)	0.210 (0.140, 0.345)	0.647 (0.382, 1.142)	31.747	<0.001
Stigmasterol	0.049 (0.045, 0.055)	0.051±0.011	0.153 (0.102, 0.230)	27.224	<0.001
Sitosterol	0.305 (0.220, 0.389)	0.340 (0.239, 0.496)	0.802 (0.553, 1.379)	15.16	<0.001
Total	0.995 (0.814, 1.171)	1.212 (0.974, 1.482)	2.826 (2.130, 5.187)	28.439	<0.001


Squalene	0.080 (0.066, 0.111)	0.089 (0.059, 0.153)	0.043±0.017	1.177	0.311
Desmosterol	0.016 (0.014, 0.019)	0.017±0.004	0.050 (0.035, 0.080)	100.475	<0.001
Lathosterol	0.154±0.034	0.191±0.075	0.099 (0.063, 0.127)	14.625	<0.001
Campesterol	0.148 (0.099, 0.240)	0.118 (0.087, 0.193)	0.105 (0.077, 0.163)	1.202	0.303
Stigmasterol	0.032 (0.028, 0.039)	0.028±0.007	0.022 (0.017, 0.032)	1.267	0.285
Sitosterol	0.208 (0.148, 0.251)	0.184 (0.155, 0.245)	0.129 (0.094, 0.174)	1.56	0.213
Total	0.672 (0.549, 0.800)	0.664 (0.575, 0.787)	0.458 (0.382, 0.565)	0.222	0.802

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Gas Chromatography and Flame-Ionization Detection of Non-Cholesterol Sterols as Indicators of Cholesterol Absorption and Synthesis in 158 Chinese Individuals with Normolipidemia, Hyperlipidemia, and Familial Hypercholesterolemia

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