Gas Chromatography and Flame-Ionization Detection of Non-Cholesterol Sterols as Indicators of Cholesterol Absorption and Synthesis in 158 Chinese Individuals with Normolipidemia, Hyperlipidemia, and Familial Hypercholesterolemia

13 February 2022 : Clinical Research

Zhi-Zhao Li^1DE*, Qi-Hui Wang^2C, Yang Liu^2C, lvya Wang^3A, Zhen-Qiu Yu^3A, Qiong Huang^4B, Jing Zhang^5B

DOI: 10.12659/MSM.934471

Med Sci Monit 2022; 28:e934471

Background Material and Methods Results Discussion Conclusions Data Availability References

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Table 3 Results of multifactorial regression analysis.

Item	B	SE	Wald	Sig.	Exp (B)	95% CI EXP (B)
Item	B	SE	Wald	Sig.	Exp (B)	LL	UL
Sex	0.509	1.021	0.248	0.618	1.663	0.225	12.312
Age (year)	0.025	0.065	0.142	0.706	1.025	0.902	1.165
BMI (kg/m)	0.005	0.109	0.002	0.965	1.005	0.812	1.244
TG (mmol/L)	5.919	1.415	17.497		372.170	23.238	5960.466
TC (mmol/L)	4.384	1.419	9.552		80.197	4.973	1293.413
HDL-C	−0.758	1.109	0.467	0.494	0.468	0.053	4.119
LDL-C	−0.697	1.318	0.280	0.597	0.498	0.038	6.593
FPG (mmol/L)	0.910	0.540	2.842	0.092	2.485	0.862	7.164
SBP (mmHg)	−0.028	0.060	0.227	0.634	0.972	0.864	1.093
DBP (mmHg)	−0.007	0.081	0.007	0.933	0.993	0.847	1.164
Squalene (%)	−0.081	0.084	0.935	0.334	0.922	0.782	1.087
Desmosterol (%)	−35.604	13.950	6.514		<0.001	<0.001	<0.001
Lathosterol (%)	0.794	0.781	1.034	0.309	2.212	0.479	10.211
Campesterol (%)	−0.457	0.883	0.268	0.605	0.633	0.112	3.572
Stigmasterol (%)	−0.413	1.689	0.060	0.807	0.662	0.024	18.136
Sitosterol (%)	0.460	0.989	0.216	0.642	1.584	0.228	11.006
Constant	−26.228	8.761	8.963	0.003	<0.001
BMI – body mass index; HDL-C – high-density lipoprotein cholesterol; LDL-C – low-density lipoprotein cholesterol; TG – triglycerides; TC – total cholesterol; FPG – fasting plasma glucose; SBP – systolic blood pressure; DBP – diastolic blood pressure; FH – familial hypercholesterolemia; SE – standard error.

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