Gas Chromatography and Flame-Ionization Detection of Non-Cholesterol Sterols as Indicators of Cholesterol Absorption and Synthesis in 158 Chinese Individuals with Normolipidemia, Hyperlipidemia, and Familial Hypercholesterolemia

13 February 2022 : Clinical Research

Zhi-Zhao Li^1DE*, Qi-Hui Wang^2C, Yang Liu^2C, lvya Wang^3A, Zhen-Qiu Yu^3A, Qiong Huang^4B, Jing Zhang^5B

DOI: 10.12659/MSM.934471

Med Sci Monit 2022; 28:e934471

Background Material and Methods Results Discussion Conclusions Data Availability References

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Table 4 Results of receiver operating characteristic curve for healthy group (n=64) and dyslipidemia group (n=69).

Item	AUC	SE	95% CT	z	P	Youden Index	Associated criterion	Sensitivity (%)	Specificity (%)
TC (mmol/L)	0.730	0.043	0.646–0.803	5.356	<0.001	0.361	>5.73	37.68	98.44
TG (mmol/L)	0.833	0.038	0.759–0.892	8.675	<0.001	0.725	>1.7	72.46	100.00
Desmosterol (%)	0.524	0.051	0.435–0.611	0.470	0.638	0.106	>0.19	30.88	79.69
Model 1	0.960	0.015	0.910–0.986	30.362	<0.001	0.821	>0.61	86.76	95.31
Model 2	0.728	0.044	0.644–0.802	5.138	<0.001	0.404	>−0.17	77.94	62.50
Model 1: TC+TG+desmosterol; Model 2: squalene+desmosterol+lathosterol+campesterol+stigmasterol+sitosterol. AUC – area under the ROC curve; SE – standard error; TC – total cholesterol; TG – triglycerides.

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