13 February 2022 : Clinical Research
Gas Chromatography and Flame-Ionization Detection of Non-Cholesterol Sterols as Indicators of Cholesterol Absorption and Synthesis in 158 Chinese Individuals with Normolipidemia, Hyperlipidemia, and Familial Hypercholesterolemia
Zhi-Zhao Li1DE*, Qi-Hui Wang2C, Yang Liu2C, lvya Wang3A, Zhen-Qiu Yu3A, Qiong Huang4B, Jing Zhang5BDOI: 10.12659/MSM.934471
Med Sci Monit 2022; 28:e934471
Table 5 Results of receiver operating characteristic curve for dyslipidemia group (n=69) and familial hypercholesterolemia group (n=25).
| Item | AUC | SE | 95% CT | z | P | Youden Index | Associated criterion | Sensitivity (%) | Specificity (%) |
|---|---|---|---|---|---|---|---|---|---|
| Squalene | 0.883 | 0.035 | 0.799–0.940 | 1.386 | 0.588 | ≤0.76 | 100.00 | 58.82 | |
| Desmosterol | 0.956 | 0.027 | 0.892–0.988 | 16.618 | 0.851 | >0.24 | 88.00 | 97.06 | |
| Lathosterol | 0.822 | 0.051 | 0.729–0.893 | 6.352 | 0.554 | ≤1.23 | 76.00 | 79.41 | |
| Campesterol | 0.581 | 0.065 | 0.475–0.683 | 1.249 | 0.212 | 0.205 | ≤0.86 | 44.00 | 76.47 |
| Stigmasterol | 0.640 | 0.076 | 0.534–0.737 | 1.853 | 0.064 | 0.337 | ≤0.19 | 44.00 | 89.71 |
| Sitosterol | 0.746 | 0.059 | 0.645–0.831 | 4.184 | 0.499 | ≤1.53 | 72.00 | 77.94 | |
| Model 3 | 1.000 | <0.001 | 0.961–1.000 | – | 1.000 | >−14.51 | 100.00 | 100.00 | |
| Model 3: squalene+desmosterol+lathosterol+campesterol+stigmasterol+sitosterol. AUC – area under the ROC curve; SE – standard error; TC – total cholesterol; TG – triglycerides. | |||||||||