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09 December 2021: Database Analysis

Low Expression of Long Noncoding RNA SLC26A4 Antisense RNA 1 Is an Independent Prognostic Biomarker and Correlate of Immune Infiltrates in Breast Cancer

Weiwei Yi 1ABCEF , Haiqing Shen 2BC , Dexi Sun 3BC , Yongchao Xu 4BC , Yujie Feng 1BC , Dongbing Li 5BC , Caixia Wang 1ABCEF*

DOI: 10.12659/MSM.934522

Med Sci Monit 2021; 27:e934522

Table 2 Expression of SLC26A4-AS1 in breast cancer is associated with clinical characteristics.

CharacteristicLow expression of SLC26A4-AS1High expression of SLC26A4-AS1pStatisticMethod
n541542
T stage, n (%)0.9090.54Chisq.test
 T1140 (13%)137 (12.7%)
 T2309 (28.6%)320 (29.6%)
 T371 (6.6%)68 (6.3%)
 T419 (1.8%)16 (1.5%)
N stage, n (%)0.5362.18Chisq.test
 N0245 (23%)269 (25.3%)
 N1179 (16.8%)179 (16.8%)
 N261 (5.7%)55 (5.2%)
 N342 (3.9%)34 (3.2%)
M stage, n (%)0.8360.04Chisq.test
 M0452 (49%)450 (48.8%)
 M111 (1.2%)9 (1%)
Pathologic stage, n (%)0.7361.27Chisq.test
 Stage I87 (8.2%)94 (8.9%)
 Stage II306 (28.9%)313 (29.5%)
 Stage III123 (11.6%)119 (11.2%)
 Stage IV11 (1%)7 (0.7%)
Race, n (%)0.9450.11Chisq.test
 Asian30 (3%)30 (3%)
 Black or African American89 (9%)92 (9.3%)
 White363 (36.5%)390 (39.2%)
Age, n (%)11.49Chisq.test
 ≤60272 (25.1%)329 (30.4%)
 >60269 (24.8%)213 (19.7%)
Histological type, n (%)0.9400.01Chisq.test
 Infiltrating ductal carcinoma387 (39.6%)385 (39.4%)
 Infiltrating lobular carcinoma104 (10.6%)101 (10.3%)
PR status, n (%)Fisher.test
 Negative141 (13.6%)201 (19.4%)
 Indeterminate2 (0.2%)2 (0.2%)
 Positive375 (36.3%)313 (30.3%)
ER status, n (%)Fisher.test
 Negative89 (8.6%)151 (14.6%)
 Indeterminate1 (0.1%)1 (0.1%)
 Positive428 (41.4%)365 (35.3%)
HER2 status, n (%)0.6240.94Chisq.test
 Negative274 (37.7%)284 (39.1%)
 Indeterminate5 (0.7%)7 (1%)
 Positive71 (9.8%)86 (11.8%)
PAM50, n (%)82.17Chisq.test
 Normal7 (0.6%)33 (3%)
 LumA291 (26.9%)271 (25%)
 LumB139 (12.8%)65 (6%)
 Her248 (4.4%)34 (3.1%)
 Basal56 (5.2%)139 (12.8%)
Menopause status, n (%)0.00212.79Chisq.test
 Pre91 (9.4%)138 (14.2%)
 Peri17 (1.7%)23 (2.4%)
 Post372 (38.3%)331 (34.1%)
Anatomic neoplasm subdivisions, n (%)0.2361.4Chisq.test
 Left271 (25%)292 (27%)
 Right270 (24.9%)250 (23.1%)
Radiation therapy, n (%)0.5760.31Chisq.test
 No219 (22.2%)215 (21.8%)
 Yes268 (27.2%)285 (28.9%)
Age, median (IQR)60 (51, 69)55 (47, 65)171329Wilcoxon

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750