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30 March 2022: Clinical Research

Follow-Up of 108 Patients with Chronic Hepatitis B Virus Infection Treated with Polyethylene Glycol-Conjugated Derivatives of Interferon-Alpha and Monitoring of Off-Treatment Virological Relapse

Liyang Zhou 1ABCDEF* , Qin He 1CEF* , Xitao Liu 2DEF* , Xiaoan Yang 3BC , Xueting Ou 1EF , Bing Situ 2DF , Yueping Li 4DE , Xingfei Pan 1DEFG* , Qihuan Xu 3AE*

DOI: 10.12659/MSM.934785

Med Sci Monit 2022; 28:e934785

Table 2 Rate of virological/clinic relapse and cumulative rate of suppression after pegylated interferon-alpha regimen was completed.

Following-up period, year
Numbers of cases10880645343
Numbers of cases losting29896
The rate of relapse0.24300.09270.05000.02060.0000
The rate of virological suppression0.75700.90730.95000.97941.0000
The cumulative rate of virological suppression0.75700.68680.65250.63910.6391
Numbers of cases10887705847
Numbers of cases lost991196
The rate of recurarence0.11590.09700.01550.03740.0000
The rate of clinical suppression0.88410.90300.98450.96261.0000
The cumulative rate of clinical suppression0.88410.79830.78590.75650.7565
37 patients with sustained viral suppression were followed up beyond 5 years. 41 patients with sustained non-recurrence were followed up beyongd 5 years.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750