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30 March 2022: Clinical Research

Follow-Up of 108 Patients with Chronic Hepatitis B Virus Infection Treated with Polyethylene Glycol-Conjugated Derivatives of Interferon-Alpha and Monitoring of Off-Treatment Virological Relapse

Liyang Zhou 1ABCDEF* , Qin He 1CEF* , Xitao Liu 2DEF* , Xiaoan Yang 3BC , Xueting Ou 1EF , Bing Situ 2DF , Yueping Li 4DE , Xingfei Pan 1DEFG* , Qihuan Xu 3AE*

DOI: 10.12659/MSM.934785

Med Sci Monit 2022; 28:e934785

Table 3 Univariate and multivariate Cox analysis of factors associated with sustained virological suppression after pegylated interferon-alpha regimen was completed.

FactorsUnivariateMultivariate
RR (95% CI)PRR (95% CI)P
HBsAg at 24 weeks1.000 (1.000~1.000)0.0221.000 (1.000~1.000)0.816
HBsAg at 36 weeks1.000 (1.000~1.000)0.0001.000 (1.000~1.000)0.717
HBsAg at 48 weeks1.000 (1.000~1.000)0.0001.000 (1.000~1.000)0.331
HBV DNA at 36 weeks1.000 (1.000~1.000)0.0281.000 (1.000~1.000)0.096
HBV DNA at 48 weeks1.000 (1.000~1.000)0.0251.000 (1.000~1.000)0.345
AST at 24 weeks0.988 (0.978~0.999)0.0290.988 (0.975~1.002)0.088
Time of treatment0.961 (0.932~0.992)0.0130.991 (0.958~1.026)0.614
ALT at 24 weeks of follow-up5.027 (2.610~9.682)0.0003.430 (1.302~9.034)0.013
Peg-IFNα – pegylated interferon alfa; HBsAg – hepatitis B surface antigen; HBV – hepatitis B virus; ALT – alanine aminotransferase; AST – aspartate aminotransferase.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750