02 March 2022 : Clinical Research
Retrospective Study of the Association Between Platelet-to-Lymphocyte Ratio in Patients with Acute Coronary Syndrome on Admission to a Rural Referral Center in East Java, Indonesia, and the Incidence of New Symptomatic Heart Failure at 6 Months
Ryan Enast Intan1ACEF, Firas Farisi Alkaff
23CEF*, Yudi Her Oktaviono1D, Ricardo Adrian Nugraha 1ACD, Tan Nicko Octora4B, Michael Jonatan 1AF, Dimas Rio Balti5ABEF, Fani Suslina Hasibuan6B, Basuni Radi 78D, Anwar Santoso78AD
DOI: 10.12659/MSM.935002
Med Sci Monit 2022; 28:e935002
Table 1 Baseline characteristics of study population.
| Variables | Totaln=92 | High PLR (≥108)n=46 | Low PLR (<108)n=46 | P value |
|---|---|---|---|---|
| Age, mean (SD) | 55.91 (9.83) | 58 (9.85) | 54 (9.46) | 0.041 |
| Man gender, n (%) | 61 (66.3) | 34 (73.9) | 27 (58.69) | 0.123 |
| Myocardial infarction, n (%) | 75 (81.52) | 41 (89.1) | 34 (73.9) | 0.060 |
| Heart rate, mean±SD | 83.86±20.20 | 82.63±18.01 | 85.12±22.37 | 0.573 |
| GRACE score, mean±SD | 110.82±32.47 | 118.89±28.21 | 102.74±34.68 | 0.016 |
| BMI, mean±SD | 24.44±3.23 | 24.57±3.28 | 24.32±3.21 | 0.713 |
| % LVEF, mean±SD | 47.14±12.04 | 45.34±11.98 | 49.07±11.96 | 0.160 |
| Symptom onset hour, median [IQR] | 6.75 [4–15.75] | 6.5 [3.90–15.50] | 7.5 [4.50–23.50] | 0.443 |
| Circadian morning onset, n (%) | 50 (54.35) | 23 (50.0) | 19 (41.3) | 0.4 |
| LMR, mean±SD | 8.63±5.55 | 8.08±5.41 | 9.95±5.77 | 0.006 |
| NLR, median [IQR] | 3.9 [2.51–5.53] | 4.27 [2.82–5.63] | 2.36 [1.19–2.54] | 0.000 |
| CKMB, median [IQR] | 32 [24.75–52] | 35 [27.65–55.42] | 26 [17.50–45.45] | 0.374 |
| Blood glucose, median [IQR] | 151 [120–227] | 159 [129–236] | 143 [86–205] | 0.463 |
| Diabetes mellitus, n (%) | 27 (29.35) | 12 (26.1) | 15 (32.6) | 0.982 |
| Hypertension, n (%) | 33 (35.87) | 24 (52.2) | 9 (19.6) | 0.001 |
| Active smoker, n (%) | 50 (54.35) | 28 (60.9) | 22 (47.8) | 0.209 |
| Family history of CVD, n (%) | 17 (18.4) | 9 (19.6) | 8 (17.4) | 0.567 |
| Length of stay, median [IQR] | 4 [–]4 | 4 [–]4 | 4 [–]4 | 0.893 |
| Beta blocker, n (%) | 80 (86.9) | 41 (89.1) | 39 (84.8) | 0.536 |
| RAAS blocker, n (%) | 82 (89.1) | 41 (89.1) | 41 (89.1) | 0.765 |
| Statin, n (%) | 92 (100) | 46 (100) | 46 (100) | 1.000 |
| DAPT, n (%) | 92 (100) | 41 (100) | 41 (100) | 1.000 |
| ACS – acute coronary syndrome; BMI – body mass index; CKMB – creatine kinase myocardial band; CVD – cardiovascular diseases; DAPT – dual anti-platelet therapy; GRACE score – Global Registry of Acute Coronary Events score; IQR – interquartile range; LMR – leucocyte-to-monocyte ratio; LVEF – left ventricular ejection fraction; NLR – neutrophil-to-lymphocyte ratio; PLR – platelet-to-lymphocyte ratio; SD – standard deviation; RAAS blocker – renin-angiotensin-aldosterone system blocker. value | ||||