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02 March 2022: Clinical Research

Retrospective Study of the Association Between Platelet-to-Lymphocyte Ratio in Patients with Acute Coronary Syndrome on Admission to a Rural Referral Center in East Java, Indonesia, and the Incidence of New Symptomatic Heart Failure at 6 Months

Ryan Enast Intan 1ACEF* , Firas Farisi Alkaff 23CEF* , Yudi Her Oktaviono 1D , Ricardo Adrian Nugraha 1ACD , Tan Nicko Octora 4B , Michael Jonatan 1AF , Dimas Rio Balti 5ABEF , Fani Suslina Hasibuan 6B , Basuni Radi 78D , Anwar Santoso 78AD

DOI: 10.12659/MSM.935002

Med Sci Monit 2022; 28:e935002

Table 1 Baseline characteristics of study population.

VariablesTotaln=92High PLR (≥108)n=46Low PLR (<108)n=46P value
Age, mean (SD)55.91 (9.83)58 (9.85)54 (9.46)0.041
Man gender, n (%)61 (66.3)34 (73.9)27 (58.69)0.123
Myocardial infarction, n (%)75 (81.52)41 (89.1)34 (73.9)0.060
Heart rate, mean±SD83.86±20.2082.63±18.0185.12±22.370.573
GRACE score, mean±SD110.82±32.47118.89±28.21102.74±34.680.016
BMI, mean±SD24.44±3.2324.57±3.2824.32±3.210.713
% LVEF, mean±SD47.14±12.0445.34±11.9849.07±11.960.160
Symptom onset hour, median [IQR]6.75 [4–15.75]6.5 [3.90–15.50]7.5 [4.50–23.50]0.443
Circadian morning onset, n (%)50 (54.35)23 (50.0)19 (41.3)0.4
LMR, mean±SD8.63±5.558.08±5.419.95±5.770.006
NLR, median [IQR]3.9 [2.51–5.53]4.27 [2.82–5.63]2.36 [1.19–2.54]0.000
CKMB, median [IQR]32 [24.75–52]35 [27.65–55.42]26 [17.50–45.45]0.374
Blood glucose, median [IQR]151 [120–227]159 [129–236]143 [86–205]0.463
Diabetes mellitus, n (%)27 (29.35)12 (26.1)15 (32.6)0.982
Hypertension, n (%)33 (35.87)24 (52.2)9 (19.6)0.001
Active smoker, n (%)50 (54.35)28 (60.9)22 (47.8)0.209
Family history of CVD, n (%)17 (18.4)9 (19.6)8 (17.4)0.567
Length of stay, median [IQR]4 [–]4 4 [–]4 4 [–]4 0.893
Beta blocker, n (%)80 (86.9)41 (89.1)39 (84.8)0.536
RAAS blocker, n (%)82 (89.1)41 (89.1)41 (89.1)0.765
Statin, n (%)92 (100)46 (100)46 (100)1.000
DAPT, n (%)92 (100)41 (100)41 (100)1.000
ACS – acute coronary syndrome; BMI – body mass index; CKMB – creatine kinase myocardial band; CVD – cardiovascular diseases; DAPT – dual anti-platelet therapy; GRACE score – Global Registry of Acute Coronary Events score; IQR – interquartile range; LMR – leucocyte-to-monocyte ratio; LVEF – left ventricular ejection fraction; NLR – neutrophil-to-lymphocyte ratio; PLR – platelet-to-lymphocyte ratio; SD – standard deviation; RAAS blocker – renin-angiotensin-aldosterone system blocker. value

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750