23 April 2022>: Clinical Research
Combining Magnetic Resonance Diffusion-Weighted Imaging with Prostate-Specific Antigen to Differentiate Between Malignant and Benign Prostate Lesions
Liying Han 1CEF , Guanyong He 1CDE , Yingjie Mei 2CD , Qing Yu 3BF , Minning Zhao 3BF , Fu Luo 4B , Guanxun Cheng 1AEG** , Wen Liang 3AE**DOI: 10.12659/MSM.935307
Med Sci Monit 2022; 28:e935307
Table 3 MRI results and PSA metrics of the two groups.
MRI/PSA metrics | PCa (n=32) | Benign (n=52) | t/Z | p |
---|---|---|---|---|
ADC (×10 mm/s) | 0.748±0.158 | 1.018±0.175 | −5.930 | 0.000* |
D (×10 mm/s) | 0.764±0.20 | 1.048±0.204 | −5.331 | 0.000* |
f | 0.137±0.039 | 0.155±0.043 | −1.878 | 0.064a |
D (×10 mm/s)* | 91.144±35.60 | 74.247±37.579 | −2.630 | 0.009* |
D (×10 mm/s) | 1.211±0.286 | 1.624±0.253 | −6.921 | 0.000* |
K | 1.135±0.193 | 0.901±0.150 | 6.200 | 0.000* |
tPSA (ng/ml) | 37.995 (19.355–231.875) | 9.415 (6.832–15.855) | −4.665 | 0.000* |
f/tPSA | 0.095±0.05 | 0.15±0.075 | −3.574 | 0.000* |
PSAD (ng/ml/cm) | 0.67(0.31–3.215) | 0.145(0.09–0.208) | −5.529 | 0.000* |
a These parameters were performed as means±standard deviations and analyzed by 2 independent sample test. b These parameters were presented as median (interquartile range) and analyzed by the Mann-Whitney U test. * MRI – magnetic resonance imaging; ADC – apparent diffusion coefficient; D – pure diffusion coefficient; f – perfusion fraction; D – pseudo/perfusion-related diffusion coefficient; D – corrected diffusion coefficient; K – Kurtosis |