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23 April 2022: Clinical Research

Combining Magnetic Resonance Diffusion-Weighted Imaging with Prostate-Specific Antigen to Differentiate Between Malignant and Benign Prostate Lesions

Liying Han 1CEF , Guanyong He 1CDE , Yingjie Mei 2CD , Qing Yu 3BF , Minning Zhao 3BF , Fu Luo 4B , Guanxun Cheng 1AEG** , Wen Liang 3AE**

DOI: 10.12659/MSM.935307

Med Sci Monit 2022; 28:e935307

Table 3 MRI results and PSA metrics of the two groups.

MRI/PSA metricsPCa (n=32)Benign (n=52)t/Zp
ADC (×10 mm/s)0.748±0.1581.018±0.175−5.9300.000*
D (×10 mm/s)0.764±0.201.048±0.204−5.3310.000*
f0.137±0.0390.155±0.043−1.8780.064a
D (×10 mm/s)* 91.144±35.6074.247±37.579−2.6300.009*
D (×10 mm/s)1.211±0.2861.624±0.253−6.9210.000*
K1.135±0.1930.901±0.1506.2000.000*
tPSA (ng/ml)37.995 (19.355–231.875)9.415 (6.832–15.855)−4.6650.000*
f/tPSA0.095±0.050.15±0.075−3.5740.000*
PSAD (ng/ml/cm)0.67(0.31–3.215)0.145(0.09–0.208)−5.5290.000*
a These parameters were performed as means±standard deviations and analyzed by 2 independent sample test.
b These parameters were presented as median (interquartile range) and analyzed by the Mann-Whitney U test.
*
MRI – magnetic resonance imaging; ADC – apparent diffusion coefficient; D – pure diffusion coefficient; f – perfusion fraction; D – pseudo/perfusion-related diffusion coefficient; D – corrected diffusion coefficient; K – Kurtosis

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750