Combining Magnetic Resonance Diffusion-Weighted Imaging with Prostate-Specific Antigen to Differentiate Between Malignant and Benign Prostate Lesions

23 April 2022 : Clinical Research

Liying Han^1CEF, Guanyong He^1CDE, Yingjie Mei^2CD, Qing Yu^3BF, Minning Zhao^3BF, Fu Luo^4B, Guanxun Cheng^1AEG*, Wen Liang^3AE

DOI: 10.12659/MSM.935307

Med Sci Monit 2022; 28:e935307

Background Material and Methods Results Discussion Conclusions References

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Table 3 MRI results and PSA metrics of the two groups.

MRI/PSA metrics	PCa (n=32)	Benign (n=52)	t/Z	p
ADC (×10 mm/s)	0.748±0.158	1.018±0.175	−5.930	0.000^*
D (×10 mm/s)	0.764±0.20	1.048±0.204	−5.331	0.000^*
f	0.137±0.039	0.155±0.043	−1.878	0.064^a
D (×10 mm/s)^*	91.144±35.60	74.247±37.579	−2.630	0.009^*
D (×10 mm/s)	1.211±0.286	1.624±0.253	−6.921	0.000^*
K	1.135±0.193	0.901±0.150	6.200	0.000^*
tPSA (ng/ml)	37.995 (19.355–231.875)	9.415 (6.832–15.855)	−4.665	0.000^*
f/tPSA	0.095±0.05	0.15±0.075	−3.574	0.000^*
PSAD (ng/ml/cm)	0.67(0.31–3.215)	0.145(0.09–0.208)	−5.529	0.000^*
^a These parameters were performed as means±standard deviations and analyzed by 2 independent sample test. ^b These parameters were presented as median (interquartile range) and analyzed by the Mann-Whitney U test. ^* MRI – magnetic resonance imaging; ADC – apparent diffusion coefficient; D – pure diffusion coefficient; f – perfusion fraction; D – pseudo/perfusion-related diffusion coefficient; D – corrected diffusion coefficient; K – Kurtosis

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