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23 April 2022: Clinical Research

Combining Magnetic Resonance Diffusion-Weighted Imaging with Prostate-Specific Antigen to Differentiate Between Malignant and Benign Prostate Lesions

Liying Han 1CEF , Guanyong He 1CDE , Yingjie Mei 2CD , Qing Yu 3BF , Minning Zhao 3BF , Fu Luo 4B , Guanxun Cheng 1AEG** , Wen Liang 3AE**

DOI: 10.12659/MSM.935307

Med Sci Monit 2022; 28:e935307

Table 4 Performance of the independent variables and combined model.

MRI/PSA metricsAUC (95% CI)CutoffSensitivitySpecificityPPVNPVP
Combined model0.911 (0.829–0.962)0.3210.8750.8650.8000.918
ADC (×10 mm/s)0.887 (0.806–0.967)0.8550.8440.8650.7940.900.204a
D (×10 mm/s)0.848 (0.755–0.941)0.870.7810.8650.7810.865
D (×10 mm/s)0.672 (0.556–0.787)66.710.8130.5190.510.818
D (×10 mm/s)0.862 (0.774–0.951)1.410.7810.8650.7810.865
K0.822 (0.725–0.920)1.0150.8130.7880.7030.872
tPSA (ng/ml)0.804 (0.693–0.915)20.9950.750.8460.750.846
f/tPSA0.733 (0.624–0.842)0.1140.7190.6920.590.80
PSAD (ng/ml/cm)0.861 (0.770–0.951)0.3350.750.9040.8280.8550.131a
PI-RADS v20.859 (0.771–0.948)>30.7810.8850.8060.8670.229a
a Delong test was used to compare the AUC of combined model and that of ADC, PSAD, and PI-RADS v2.
AUC – area under curve; PPV – positive predictive value; NPV – negative predictive value; PI-RADS v2 – Prostate Imaging Reporting and Data System version 2.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750