The Correlation of Mouse Double Minute 4 (MDM4) Polymorphisms (rs4245739, rs1563828, rs11801299, rs10900598, and rs1380576) with Cancer Susceptibility: A Meta-Analysis

Jian Chen; Xudong Li; Ruihao Liu; Yufen Xie; Zhigao Liu; Haiwei Xiong; Yingliang Li

doi:10.12659/MSM.935671

29 March 2022: Meta-Analysis

The Correlation of Mouse Double Minute 4 (MDM4) Polymorphisms (rs4245739, rs1563828, rs11801299, rs10900598, and rs1380576) with Cancer Susceptibility: A Meta-Analysis

Jian Chen ^1ABCDEF , Xudong Li ^2BCD , Ruihao Liu ^1DEF , Yufen Xie ^1DE , Zhigao Liu ^1CE , Haiwei Xiong ^1CE , Yingliang Li ^1ACG*

DOI: 10.12659/MSM.935671

Med Sci Monit 2022; 28:e935671

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Table 2 Characteristics of the included studies.

Author	Year	Cancer-type	Country	Ethnicity	Control source	Genotype method	Case			Control			HWE (Control)

Garcia-Closas	2013	Breast cancer	Multi-center	Caucasian	Mixed	Illumina array	3318	2637	557	22825	15798	2828	0.412
JB Liu	2013	Breast cancer	China	Asian	PB	PCR-RFLP	733	67	0	686	111	3	0.801
JB Liu	2013	Breast cancer	China	Asian	PB	PCR-RFLP	278	22	0	501	96	3	0.782
LQ Zhou	2013	ESCC	China	Asian	PB	PCR-RFLP	501	37	2	478	70	2	0.946
LQ Zhou	2013	ESCC	China	Asian	PB	PCR-RFLP	529	56	3	510	88	2	0.679
CB Fan	2014	NHL	China	Asian	PB	PCR-RFLP	187	13	0	346	53	1	0.785
JB Feng	2014	Gastric cancer	China	Asian	HB	PCR-RFLP	208	209	51	210	219	64	0.845
Gansmo	2015	Breast cancer	Norway	Caucasian	PB	LightSNiP assay	966	643	108	1021	703	146	0.271
Gansmo	2015	Colon cancer	Norway	Caucasian	PB	LightSNiP assay	823	600	108	2042	1439	266	0.848
Gansmo	2015	Lung cancer	Norway	Caucasian	PB	LightSNiP assay	715	515	101	2042	1439	266	0.848
Gansmo	2015	Prostate cancer	Norway	Caucasian	PB	LightSNiP assay	1412	927	161	1021	736	120	0.271
F Gao	2015	Lung cancer	China	Asian	PB	PCR-RFLP	297	22	1	548	90	2	0.701
F Gao	2015	Lung cancer	China	Asian	PB	PCR-RFLP	183	17	0	321	77	2	0.514
Pedram	2016	Breast cancer	Iran	Caucasian	HB	T-ARMS-PCR assay	123	87	10	165	81	14	0.061
Gansmo	2016	Ovarian cancer	Norway	Caucasian	PB	LightSNiP assay	716	564	105	1021	703	146	0.271
Gansmo	2016	Endometrial cancer	Norway	Caucasian	PB	LightSNiP assay	757	541	106	1021	703	146	0.271
Khanlou	2017	Thyroid cancer	Iran	Caucasian	HB	T-ARMS-PCR assay	63	34	5	144	76	12	0.893
Hashemi	2018	Breast cancer	Iran	Caucasian	HB	T-ARMS-PCR assay	175	83	7	142	70	9	0.995
Pedram	2020	Breast cancer	Iran	Caucasian	PB	T-ARMS-PCR assay	114	82	10	120	68	11	0.946
DM Zhao	2020	Colorectal cancer	China	Asian	HB	MassARRAY	304	128	11	323	180	25	1.000
Kotarac	2020	Prostate cancer	Serbia	Caucasian	HB	TaqMan	198	131	23	182	144	31	0.890
Tripon	2020	AML	Romania	Caucasian	HB	T-ARMS-PCR assay	202	144	57	209	114	83

CG Song	2012	Breast cancer	China	Asian	HB	MassArray	53	57	14	44	43	14	0.802
YW Zhang	2012	NPC	China	Asian	PB	RT-PCR	98	91	21	90	88	22	0.998
Thunell	2014	Hereditary melanoma	Sweden	Caucasian	PB	RT-PCR	27	21	2	389	340	70	0.940

HP Yu	2011	SCCHN	America	Caucasian	HB	TaqMan	487	477	111	518	455	106	0.917
HP Yu	2012	SCCHN	America	Caucasian	HB	TaqMan	170	158	43	150	135	36	0.798
GC Wu	2015	Gastric cancer	China	Asian	HB	TaqMan	188	281	173	212	290	218
MY Wang	2017	Gastric cancer	China	Asian	HB	TaqMan	487	493	97	552	485	136	0.180
Hashemi	2018	Breast cancer	Iran	Caucasian	HB	T-ARMS-PCR assay	86	151	26	44	142	27
FH Yu	2019	Retinobla-stoma	China	Asian	HB	TaqMan	77	39	10	71	59	18	0.426

HP Yu	2011	SCCHN	America	Caucasian	HB	TaqMan	684	351	40	665	376	38	0.229
HP Yu	2012	SCCHN	America	Caucasian	HB	TaqMan	118	179	74	202	109	10	0.589
MY Wang	2017	Gastric cancer	China	Asian	HB	TaqMan	380	539	158	449	532	192	0.271
Hashemi	2018	Breast cancer	Iran	Caucasian	HB	T-ARMS-PCR assay	183	75	6	164	50	4	0.997
FH Yu	2019	Retinobla-stoma	China	Asian	HB	TaqMan	39	49	38	57	64	27	0.491

HP Yu	2011	SCCHN	America	Caucasian	HB	TaqMan	307	545	223	296	552	231	0.677
HP Yu	2012	SCCHN	America	Caucasian	HB	TaqMan	233	126	12	93	156	72	0.913
MY Wang	2017	Gastric cancer	China	Asian	HB	TaqMan	547	447	83	604	462	107	0.393
ESCC – esophageal squamous cell carcinoma; NHL – non-Hodgkin lymphoma; NPC – nasopharyngeal cancer; SCCHN – squamous cell carcinoma of the head and neck; AML – acute myeloid leukemia.

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The Correlation of Mouse Double Minute 4 (MDM4) Polymorphisms (rs4245739, rs1563828, rs11801299, rs10900598, and rs1380576) with Cancer Susceptibility: A Meta-Analysis

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