29 March 2022 : Meta-Analysis
The Correlation of Mouse Double Minute 4 (MDM4) Polymorphisms (rs4245739, rs1563828, rs11801299, rs10900598, and rs1380576) with Cancer Susceptibility: A Meta-Analysis
Jian Chen1ABCDEF, Xudong Li2BCD, Ruihao Liu1DEF, Yufen Xie1DE, Zhigao Liu1CE, Haiwei Xiong1CE, Yingliang Li1ACG*DOI: 10.12659/MSM.935671
Med Sci Monit 2022; 28:e935671
Table 3 Summary of the association between MDM4 polymorphisms (X>Y#) and cancers.
| SNPs | N | Dominant model (XY+YY vs XX) | Recessive model (YY vs XY+XX) | Heterozygous model (XY vs XX) | Homozygous model (YY vs XX) | Additive model (Y vs X) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P/I2 (%) | OR (95% CI) | P/I2 (%) | OR (95% CI) | P/I2 (%) | OR (95% CI) | P/I2 (%) | OR (95% CI) | P/I2 (%) | ||
| 60 | 0.96 (0.85, 1.08) | 0.038/ 38.5% | 0.95 (0.82, 1.10) | 0.003/ 51.7% | |||||||
| BC | 46 | 0.90 (0.72, 1.13) | <0.001/ 87.9% | 0.90 (0.64,1.28) | 0.008/ 65.2% | 0.92 (0.74, 1.15) | <0.001/ 85.3% | 0.92 (0.62, 1.36) | 0.002/ 70.8% | 0.88 (0.72, 1.08) | <0.001/ 89.0% |
| ESCC | 2 | 1.28 (0.34, 4.76) | 0.763/ 0.0% | 1.20 (0.32, 4.48) | 0.759/ 0.0% | ||||||
| GCC | 3 | 0.91 (0.74, 1.11) | 0.053/ 66.0% | 0.90 (0.74, 1.09) | 0.196/ 38.6% | 0.94 (0.78, 1.12) | 0.125/ 51.9% | 0.82 (0.58, 1.16) | 0.118/ 53.2% | 0.90 (0.75, 1.08) | 0.029/ 71.9% |
| LC | 3 | 0.59 (0.29, 1.20) | <0.001/ 90.5% | 1.07 (0.84, 1.35) | 0.814/ 0.0% | 0.58 (0.29, 1.19) | <0.001/ 90.0% | 1.07 (0.84, 1.37) | 0.762/ 0.0% | 0.61 (0.31, 1.19) | <0.001/ 90.4% |
| PC | 2 | 0.90 (0.81, 1.01) | 0.433/ 0.0% | 0.96 (0.77, 1.20) | 0.312/ 2.1% | 0.90 (0.80, 1.01) | 0.618/ 0.0% | 0.92 (0.73, 1.15) | 0.271/ 17.5% | 0.93 (0.85, 1.02) | 0.299/ 7.4% |
| Other* | 4 | 0.99 (0.81, 1.21) | 0.044/ 63.1% | 0.96 (0.80, 1.16) | 0.997/ 0.0% | 1.00 (0.81, 1.23) | 0.045/ 62.8% | 1.00 (0.83, 1.20) | 0.985/ 0.0% | 0.99 (0.85, 1.15) | 0.062/ 59.0% |
| Asian | 9 | ||||||||||
| Caucasian | 51 | 1.04 (0.96, 1.12) | 0.001/ 64.1% | 0.99 (0.88, 1.13) | 0.019/ 51.7% | 1.04 (0.98, 1.12) | 0.024/ 50.1% | 1.00 (0.86, 1.16) | 0.002/ 62.4% | 1.02 (0.95, 1.09) | <0.001/ 70.5% |
| HB | 7 | 0.90 (0.79,1.02) | 0.130/ 41.4% | 0.93 (0.82,1.07) | 0.162/ 36.7% | ||||||
| PB | 13 | 0.96 (0.87,1.06) | 0.941/ 0.0% | 0.97 (0.87,1.07) | 0.911/ 0.0% | ||||||
| Mixed | 40 | 1.28 (1.16,1.40) | −/− | 1.35 (1.23,1.49) | −/− | ||||||
| 4 | 1.02 (0.86, 1.21) | 0.104/ 51.4% | 0.89 (0.75, 1.06) | 0.264/ 24.5% | 1.09 (0.97, 1.22) | 0.144/ 44.5% | 0.93 (0.77, 1.12) | 0.207/ 34.1% | 0.98 (0.86, 1.12) | 0.092/ 53.4% | |
| Asian | 2 | 0.83 (0.46, 1.50) | 0.020/ 81.7% | 0.88 (0.47, 1.63) | 0.022/ 80.9% | 0.77 (0.59, 1.01) | 0.313/ 1.9% | 0.83 (0.55, 1.24) | 0.040/ 76.2% | ||
| Caucasian | 2 | 1.10 (0.95, 1.27) | 0.681/ 0.0% | 1.05 (0.83, 1.34) | 0.948/ 0.0% | 1.09 (0.94, 1.28) | 0.680/ 0.0% | 1.10 (0.85, 1.41) | 0.850/ 0.0% | 1.07 (0.95, 1.19) | 0.735/ 0.0% |
| 5 | 1.47 (0.94, 2.30) | <0.001/ 93.1% | 1.75 (0.85, 3.60) | <0.001/ 90.0% | 1.35 (0.93, 1.96) | <0.001/ 88.7% | 2.01 (0.86, 4.71) | <0.001/ 92.0% | 1.41 (0.94, 2.12) | <0.001/ 94.9% | |
| Asian | 2 | 1.16 (0.99, 1.37) | 0.448/ 0.0% | 1.25 (0.58, 2.69) | 0.011/ 84.5% | 1.19 (1.00, 1.41) | 0.820/ 0.0% | 1.33 (0.65, 2.75) | 0.033/ 78.1% | 1.19 (0.84, 1.70) | 0.045/ 75.1% |
| Caucasian | 3 | 1.64 (0.68, 3.97) | <0.001/ 96.4% | 2.21 (0.51, 9.55) | <0.001/ 91.7% | 1.50 (0.73, 3.09) | <0.001/ 94.3% | 2.63 (0.43,16.1) | <0.001/ 94.5% | 1.56 (0.70, 3.48) | <0.001/ 97.1% |
| 3 | 0.63 (0.31,1.26) | <0.001/ 96.9% | 0.48 (0.21, 1.13) | <0.001/ 95.0% | 0.70 (0.40, 1.25) | <0.001/ 95.0% | 0.40 (0.13, 1.18) | <0.001/ 96.5% | 0.66 (0.37, 1.17) | <0.001/ 97.7% | |
| Asian | 1 | 1.03 (0.87, 1.21) | −/− | 0.83 (0.62, 1.12) | −/− | 1.07 (0.40, 1.27) | −/− | 0.86 (0.63, 1.17) | −/− | 0.98 (0.86, 1.12) | −/− |
| Caucasian | 2 | 0.48 (0.13, 1.83) | <0.001/ 98.1% | 0.34 (0.04, 2.77) | <0.001/ 97.5% | 0.56 (0.19, 1.61) | <0.001/ 96.6% | 0.25 (0.02, 3.44) | <0.001/ 98.2% | 0.53 (0.16, 1.73) | <0.001/ 98.7% |
| 3 | 0.93 (0.71, 1.22) | 0.825/ 0.0% | 0.78 (0.49,1.23) | 0.657/ 0.0% | 0.97 (0.73, 1.30) | 0.867/ 0.0% | 0.77 (0.47, 1.24) | 0.642/ 0.0% | 0.91 (0.74, 1.12) | 0.750/ 0.0% | |
| Asian | 2 | 0.97 (0.71, 1.33) | 0.764/ 0.0% | 0.86 (0.52, 1.40) | 0.804/ 0.0% | 1.00 (0.72, 1.39) | 0.678/ 0.0% | 0.86 (0.51, 1.45) | 0.921/ 0.0% | 0.95 (0.75, 1.20) | 0.928/ 0.0% |
| Caucasian | 1 | 0.81 (0.46, 1.43) | −/− | 0.43 (0.10, 1.82) | −/− | 0.89 (0.49, 1.60) | −/− | 0.41 (0.10, 1.77) | −/− | 0.78 (0.49, 1.24) | −/− |
| * indicates meaningful results; # X: major allele, Y: minor allele. BC – breast cancer; ESCC – esophageal squamous cell carcinoma; GCC – gastric cancer and colorectal cancer; LC – lung cancer; PC – prostate cancer, Other* – ovarian cancer, endometrial cancer, thyroid cancer, and non-Hodgkin lymphoma; HB – hospital-based; PB – population-based. | |||||||||||