08 June 2022 : Clinical Research
Association Between Variants of the Mannose-Binding Lectin 2 Gene and Susceptibility to Sepsis in the Hainan Island
Shaowen ChengABCDEFG, Junyu ZhuABCDE, Xini LiuCDEF, Jian YangAEF, Wei ZhangBCD, Zhihua HuAEF, Jiemiao OuyangADF, Huaping LiangAEFGDOI: 10.12659/MSM.936134
Med Sci Monit 2022; 28:e936134
Table 1 Overall clinical characteristics of patients in the sepsis group and non-sepsis group.
| Sepsis group | Non sepsis group | P value | |
|---|---|---|---|
| Age (years) | 59.2±13.6 | 64.3±12.8 | 0.58 |
| Gender | 0.81 | ||
| Female | 94 (34.7%) | 119 (38.4%) | |
| Male | 177 (65.3%) | 191 (61.6%) | |
| Source of infection | |||
| Respiratory tract infection | 85 (31.4%) | ||
| Primary bloodstream infection | 63 (23.2%) | ||
| Urinary tract infection | 47 (17.3%) | ||
| Catheter associated infection | 37 (13.7%) | ||
| Wound infection | 34 (12.5%) | ||
| Others | 33 (12.2%) | ||
| Pathogens (positive blood cultures) | |||
| Gram-positive | 54 (20.0%) | ||
| Gram-negative | 42 (15.5%) | ||
| Fungi | 6 (2.2%) | ||
| Mixed Gram-negative and Gram-positive | 19 (7.0%) | ||
| Negative blood cultures | |||
| Number of organs with dysfunction, n (%) | 150 (55.3%) | ||
| 1 | 98 (36.2%) | ||
| 2 | 75 (27.7%) | ||
| 3 or more | 12 (4.4%) | ||
| Two independent groups existed, sepsis and non-sepsis, which consisted of 271 and 310 individuals, respectively. The main clinical characteristics of patients are presented in Table 1. The mean age and gender of patients were not significantly different between the two groups. The source of infection in patients with sepsis was mainly a respiratory tract infection (31.4%, n=85). Gram-positive and Gram-negative infections, fungal infections, and mixed infections accounted for approximately 20.0%, 15.5%, 2.2%, and 7.0%, respectively, of cases in the sepsis group. The common pathogens identified in this study were , , , , and . Negative blood cultures were identified in 55.3% of patients in the sepsis group. | |||