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08 June 2022: Clinical Research

Association Between Variants of the Mannose-Binding Lectin 2 Gene and Susceptibility to Sepsis in the Hainan Island

Shaowen Cheng 123ABCDEFG* , Junyu Zhu 4ABCDE* , Xini Liu 5CDEF* , Jian Yang 12AEF , Yudie Wang 6BCD , Wei Zhang 6BCD , Zhihua Hu 7AEF* , Jiemiao Ouyang 8ADF* , Huaping Liang 4AEFG*

DOI: 10.12659/MSM.936134

Med Sci Monit 2022; 28:e936134

Table 1 Overall clinical characteristics of patients in the sepsis group and non-sepsis group.

Sepsis groupNon sepsis groupP value
Age (years)59.2±13.664.3±12.80.58
Female94 (34.7%)119 (38.4%)
Male177 (65.3%)191 (61.6%)
Source of infection
Respiratory tract infection85 (31.4%)
Primary bloodstream infection63 (23.2%)
Urinary tract infection47 (17.3%)
Catheter associated infection37 (13.7%)
Wound infection34 (12.5%)
Others33 (12.2%)
Pathogens (positive blood cultures)
Gram-positive54 (20.0%)
Gram-negative42 (15.5%)
Fungi6 (2.2%)
Mixed Gram-negative and Gram-positive19 (7.0%)
Negative blood cultures
Number of organs with dysfunction, n (%)150 (55.3%)
 198 (36.2%)
 275 (27.7%)
 3 or more12 (4.4%)
Two independent groups existed, sepsis and non-sepsis, which consisted of 271 and 310 individuals, respectively. The main clinical characteristics of patients are presented in Table 1. The mean age and gender of patients were not significantly different between the two groups. The source of infection in patients with sepsis was mainly a respiratory tract infection (31.4%, n=85). Gram-positive and Gram-negative infections, fungal infections, and mixed infections accounted for approximately 20.0%, 15.5%, 2.2%, and 7.0%, respectively, of cases in the sepsis group. The common pathogens identified in this study were , , , , and . Negative blood cultures were identified in 55.3% of patients in the sepsis group.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750