08 June 2022: Clinical Research
Association Between Variants of the Mannose-Binding Lectin 2 Gene and Susceptibility to Sepsis in the Hainan Island
Shaowen Cheng 123ABCDEFG* , Junyu Zhu 4ABCDE* , Xini Liu 5CDEF* , Jian Yang 12AEF , Yudie Wang 6BCD , Wei Zhang 6BCD , Zhihua Hu 7AEF* , Jiemiao Ouyang 8ADF* , Huaping Liang 4AEFG*DOI: 10.12659/MSM.936134
Med Sci Monit 2022; 28:e936134
Table 3 Genotypic and allelic frequency distribution of rs1800450 in the sepsis group and non-sepsis group. P=0.014 for dominant association (GA+AA vs GG). P=0.971 for recessive association (AA vs GA+GG).
| Genotype | Sepsis group n/% | Non-sepsis group n/% | P | χ2 | OR | 95% CI |
|---|---|---|---|---|---|---|
| 271 | 310 | |||||
| GG | 193 (71.2) | 248 (80.0) | ||||
| GA | 72 (26.6) | 55 (17.7) | 0.010 | 6.622 | 1.682 | 1.130–2.505 |
| AA | 6 (2.2) | 7 (2.3) | ||||
| G | 458 (84.5) | 551 (87.9) | ||||
| A | 84 (15.5) | 69 (12.1) | 0.028 | 4.828 | 1.465 | 1.041–2.061 |
| GA+AA | 78 (28.8) | 62 (20.0) | 0.014 | 6.098 | 0.619 | 0.422–0.907 |
| GA+GG | 265 (97.8) | 303 (97.7) | 0.971 | 0.01 | 1.020 | 0.339–3.074 |
| P=0.014 for dominant association (GA+AA vs GG). P=0.971 for recessive association (AA vs GA+GG). The frequency of a GA genotype was significantly higher in the sepsis group than in the non-sepsis group (P=0.010). Allele frequency analysis also showed that the frequency of the A allele in the sepsis group was much higher than that in the non-sepsis group (P=0.029; Table 3). χ analysis showed that GA genotype patients were 1.682 times more likely to develop sepsis than GG genotype patients (OR=1.682, 95% CI=1.340–2.505). Patients who carried the A allele were more likely to acquire sepsis than G allele carriers (OR=1.465, 95% CI=1.041–2.061), which means that the variation of rs1800450, G→A increased the incidence of sepsis (Table 3). | ||||||