02 June 2022>: Database Analysis
Effect of Clemastine Fumarate on Perioperative Hemodynamic Instability Mediated by Anaphylaxis During Cardiopulmonary Bypass Surgery
Lijuan Tian 1ABCDEF* , Yue Liu 1ACDE* , Yuda Fei 2DF , Hong Lv 1BF , Fuxia Yan 1BF , Lihuan Li 1ABDEF , Jia Shi 1ABDF*DOI: 10.12659/MSM.936367
Med Sci Monit 2022; 28:e936367
Table 1 Comparison of demographic and surgical data.
Variable | Treatment group (n=50) | Placebo group (n=50) | P values |
---|---|---|---|
Age (years, χ̄±S) | 56.5±10.6 | 58.8±11.2 | 0.30 |
Male (n, %) | 34 (68.0) | 30 (60.0) | 0.53 |
Body weight (kg, χ̄±S) | 70.0±12.2 | 67.1±12.1 | 0.24 |
Diabetes mellitus (n, %) | 9 (18.0) | 12 (24.0) | 0.62 |
Hypertension (n, %) | 20 (40.0) | 23 (46.0) | 0.69 |
Cerebral vascular diseases (n, %) | 3 (6.0) | 5 (10.0) | 0.72 |
History of allergy (n, %) | 14 (28.0) | 12 (24.0) | 0.82 |
Preoperative laboratory test | |||
Platelet count (×10/L, χ̄±S) | 201.2±57.9 | 205.7±55.3 | 0.69 |
Hemoglobin (g/L, χ̄±S) | 137.4±15.3 | 139.7±18.3 | 0.87 |
Aspartate aminotransferase (U/L, χ̄±S) | 25.8±11.9 | 29.9±21.1 | 0.24 |
Alanine aminotransferase(U/L, χ̄±S) | 26.7±23.9 | 32.5±36.5 | 0.35 |
Creatinine (μmol/L, χ̄±S) | 81.3±13.9 | 81.1±16.8 | 0.96 |
Type of cardiac surgery (n, %) | 0.25 | ||
Isolated coronary operation | 27 (54.0) | 20 (40.0) | |
Isolated valve surgery | 17 (34.0) | 18 (36.0) | |
Congenital heart surgery | 3 (6.0) | 9 (18.0) | |
Combined procedures | 3 (6.0) | 3 (6.0) | |
Operation time [min, M (IQR)] | 225.0 (200.0~247.8) | 237.5 (200.2~266.3) | 0.49 |
Cardiopulmonary bypass time [min, M (IQR)] | 94.5 (83.0~110.3) | 91.5 (68.8~113.8) | 0.83 |
Norepinephrine treatment (n, %) | 15 (30.0) | 23 (46.0) | 0.15 |
There were no significant differences between groups at baseline. |