07 June 2022 : Clinical Research
Clinical Application of C-TIRADS Category and Contrast-Enhanced Ultrasound in Differential Diagnosis of Solid Thyroid Nodules Measuring ≥1 cm
Zhuang Jin1ABCDEF, Yaqiong Zhu2ABCDEF, Yu Lei3BF, Xin Yu1BCD, Nan Jiang1BCD, Yue Gao1CF, Junying Cao1ACDEF*DOI: 10.12659/MSM.936368
Med Sci Monit 2022; 28:e936368
Table 4 Comparison of CEUS characteristics of thyroid nodules.
| Benign(n=53) | Malignant(n=63) | P-value | |
|---|---|---|---|
| Enhancement intensity | 0.067 | ||
| No enhancement | 4 | 0 | |
| Hypo-enhancement | 11 | 20 | |
| Iso-enhancement | 34 | 35 | |
| Hyperenhancement | 4 | 8 | |
| Patterns of enhancement | <0.001 | ||
| Centrality | 11 | 40 | |
| Diffuse | 42 | 16 | |
| Centrifugal | 0 | 7 | |
| Internal homogeneity | 0.01 | ||
| Homogeneity | 26 | 17 | |
| Heterogeneity | 27 | 46 | |
| Wash-in | <0.001 | ||
| Earlier | 5 | 12 | |
| Synchronous | 38 | 18 | |
| Later | 10 | 33 | |
| Wash-out | <0.001 | ||
| Earlier | 0 | 3 | |
| Synchronous | 53 | 39 | |
| Later | 0 | 21 | |
| Ring enhancement | 0.003 | ||
| No | 44 | 62 | |
| Yes | 9 | 1 | |
| Morphology | <0.001 | ||
| Regular | 49 | 26 | |
| Irregular | 4 | 37 | |
| Boundary | 0.06 | ||
| Clear | 46 | 46 | |
| Unclear | 7 | 17 | |
| CAR | <0.001 | ||
| No | 53 | 45 | |
| Yes | 0 | 18 | |
| CEUS – contrast enhanced ultrasound; CAR – contrast agent retention. | |||