Serum Calprotectin – a NET Product – as a Biomarker of Disease Activity in Patients with Systemic Lupus Erythematosus: A Single-Center Case-Control Study from Poland

13 July 2022 : Clinical Research

Iwona Homa-Mlak^1ACDEF*, Marcin Mazurek^1BCEF, Aleksandra Majdan

^1DEF, Radosław Mlak^1ACDE, Maria Majdan

^2ADEF, Teresa Mełecka-Massalska^1ADEF

DOI: 10.12659/MSM.936534

Med Sci Monit 2022; 28:e936534

Background Material and Methods Results Discussion Conclusions References

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Table 4 Correlation between selected clinical and laboratory factors and calprotectin.

Variable	n	rho	p
Age (years)	59	−0.146	0.2664
Duration of the disease (years)	58	0.0388	0.7695
SLEDAI – Mild vs moderate and severe	59	0.167	0.2056
SLEDAI – Mild and moderate vs severe	59	0.0523	0.6942
RBC [10/μl]	59	−0.122	0.3515
HGB [g/dl]	59	−0.0108	0.9343
WBC [10/μl]	59	−0.236	0.0726
NEUTR [10/μl]	59	−0.171	0.1934
LYM [10/μl]	59	−0.227	0.0833
PLT [10/μl]	59	−0.114	0.3867
ESR [mm/h]	58	−0.122	0.3562
CRP [mg/l]	59	0.0625	0.6342
Total protein [g/dl]	41	0.259	0.1016
Creatinine [mg/dl]	59	−0.223	0.0899
GFR [ml/min/1.73 m]	59	0.130	0.5435
dsDNA	59	0.325	0.0277^*
C3	59	−0.429	0.0012^*
C4	28	−0.291	0.1375
IgG [mg/dl]	23	0.395	0.0637
IgM [mg/dl]	23	0.0356	0.8674
IgA [mg/dl]	26	0.0005	0.9982
^* Statistically significant results. C3 – complement component 3;C4 – complement component 4; CRP – C reactive protein; dsDNA – double-stranded DNA; GFR – glomerular filtration rate; HGB – haemoglobin; IgA – immunoglobulin A; IgG – immunoglobulin G; IgM – immunoglobulin M; LYM – lymphocytes; n – number; NEUTR – neutrophils; ESR – erythrocyte sedimentation rate; PLT – platelets; RBC – red blood cells; SLEDAI – Systemic Lupus Erythematosus Disease Activity Indexl WBC – white blood cells.

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