10 August 2022: Clinical Research
A Retrospective Study from a Single Center to Identify Hematological Factors that Distinguish Between Patients with Colorectal Carcinoma and Colorectal Adenoma
Jun Huang 12AE , Pingping Xu 3BCD , Youxiang Chen 4AE*DOI: 10.12659/MSM.936745
Med Sci Monit 2022; 28:e936745
Table 1 Demographic and clinicopathological characteristics of selected patients.
| Characteristic | Total (n=856) | Groups | Statistics | P | |
|---|---|---|---|---|---|
| Training set (n=600) | Testing set (n=256) | ||||
| Gender, n (%) | χ=0.110 | 0.740 | |||
| Male | 511 (59.70) | 356 (59.33) | 155 (60.55) | ||
| Female | 345 (40.30) | 244 (40.67) | 101 (39.45) | ||
| Age, years, Mean±SD | 56.39±12.15 | 56.16±12.43 | 56.94±11.46 | t=−0.860 | 0.393 |
| BMI, kg/m, Mean±SD | 22.45±3.38 | 22.40±3.42 | 22.56±3.30 | t=−0.640 | 0.526 |
| Diabetes, n (%) | χ=0.351 | 0.553 | |||
| No | 818 (95.56) | 575 (95.83) | 243 (94.92) | ||
| Yes | 38 (4.44) | 25 (4.17) | 13 (5.08) | ||
| Inflammatory disease, n (%) | χ=0.380 | 0.537 | |||
| No | 706 (82.48) | 498 (83.00) | 208 (81.25) | ||
| Yes | 150 (17.52) | 102 (17.00) | 48 (18.75) | ||
| Hb, g/L, Mean±SD | 125.14±24.58 | 125.48±24.67 | 124.35±24.38 | t=0.620 | 0.538 |
| RBC, 101/L, Mean±SD | 4.21±0.65 | 4.24±0.63 | 4.14±0.68 | t=1.520 | 0.094 |
| WBC, 10/L, M (Q, Q) | 5.87 (4.77, 7.34) | 5.91 (4.82, 7.22) | 5.78 (4.66, 7.63) | Z=−0.011 | 0.992 |
| NEUT, 10/L, M (Q, Q) | 3.67 (2.83, 5.15) | 3.69 (2.89, 5.01) | 3.66 (2.75, 5.50) | Z=−0.051 | 0.959 |
| LYM, 10/L, M (Q, Q) | 1.42 (1.07, 1.80) | 1.43 (1.09, 1.79) | 1.37 (1.06, 1.80) | Z=−0.742 | 0.458 |
| MONO, 10/L, M (Q, Q) | 0.35 (0.26, 0.46) | 0.35 (0.26, 0.47) | 0.35 (0.25, 0.46) | Z=−0.411 | 0.681 |
| PLT, 10/L, M (Q, Q) | 227.00 (181.00, 281.00) | 229.00 (181.00, 284.00) | 221.00 (180.50, 272.50) | Z=−0.687 | 0.492 |
| MPV, fL, Mean±SD | 10.14±1.49 | 10.20±1.49 | 9.98±1.49 | t=1.950 | 0.051 |
| PCT, %, M (Q, Q) | 0.23 (0.19, 0.27) | 0.23 (0.19, 0.28) | 0.22 (0.19, 0.27) | Z=−1.509 | 0.131 |
| RDW, %, Mean±SD | 13.51 ±2.39 | 13.59±2.52 | 13.32±2.04 | t=1.640 | 0.101 |
| PT, s, Mean±SD | 11.25 ±1.01 | 11.25±0.98 | 11.28±1.08 | t=−0.400 | 0.686 |
| APTT, s, Mean±SD | 26.76 ±4.17 | 26.83±4.18 | 26.60±4.12 | t=0.730 | 0.463 |
| TT, s, Mean±SD | 18.31 ±1.79 | 18.27±1.72 | 18.41±1.95 | t=−1.030 | 0.301 |
| FIB, g/L, Mean±SD | 3.07±0.84 | 3.06±0.84 | 3.10±0.84 | t=−0.710 | 0.479 |
| D-dimer, mg/L, M (Q, Q) | 0.30 (0.17, 0.60) | 0.31 (0.17, 0.62) | 0.30 (0.17, 0.56) | Z=−0.548 | 0.584 |
| CEA, ng/mL, M (Q, Q) | 1.86 (0.90, 3.51) | 1.82 (0.90, 3.80) | 1.93 (0.88, 3.26) | Z=−0.688 | 0.492 |
| Carbohydrate antigen 199, U/mL, M (Q, Q) | 10.94 (6.80, 19.42) | 10.84 (6.89, 20.45) | 11.03 (6.61, 17.54) | Z=−1.019 | 0.308 |
| Carbohydrate antigen 125, U/mL, M (Q, Q) | 8.50 (5.90, 12.65) | 8.60 (6.30, 12.50) | 8.40 (5.60, 13.20) | Z=−0.600 | 0.549 |
| GPT, U/L, M (Q, Q) | 16.00 (11.30, 24.00) | 16.00 (11.00, 24.00) | 16.00 (12.00, 25.10) | Z=0.958 | 0.338 |
| GOT, U/L, M (Q, Q) | 21.00 (17.00, 26.00) | 21.00 (17.00, 26.00) | 21.00 (17.00, 27.00) | Z=0.587 | 0.557 |
| TBil, μmol/L, M (Q, Q) | 13.00 (9.25, 17.80) | 13.00 (9.30, 17.80) | 12.90 (9.20, 17.90) | Z=−0.230 | 0.818 |
| ALB+GLB, g/L, Mean±SD | 66.61±7.48 | 66.72±7.47 | 66.36±7.53 | t=0.650 | 0.518 |
| ALB, g/L, Mean±SD | 41.63±4.90 | 41.70±4.78 | 41.45±5.18 | t=0.690 | 0.493 |
| GLB, g/L, Mean±SD | 24.99±4.56 | 25.02±4.60 | 24.91±4.48 | t=0.320 | 0.747 |
| A/G, Mean±SD | 1.71±0.33 | 1.71±0.32 | 1.71±0.33 | t=0.220 | 0.829 |
| BUN, mmol/L, M (Q, Q) | 4.80 (3.80, 5.80) | 4.80 (3.75, 5.80) | 4.80 (3.90, 5.80) | Z=0.637 | 0.524 |
| Cr, μmol/L, M (Q, Q) | 71.00 (61.00, 84.00) | 71.00 (61.00, 84.00) | 73.00 (61.00, 84.50) | Z=0.547 | 0.584 |
| UA, μmol/L, M (Q, Q) | 288.00 (221.00, 359.00) | 286.00 (220.00, 360.00) | 291.00 (225.50, 355.00) | Z=0.235 | 0.815 |
| NLR, M (Q, Q) | 2.56 (1.80, 4.09) | 2.55 (1.81, 3.95) | 2.62 (1.76, 4.51) | Z=0.561 | 0.575 |
| PLR, M (Q, Q) | 157.96 (115.67, 231.33) | 156.44 (116.62, 229.85) | 162.19 (115.26, 236.76) | Z=0.437 | 0.662 |
| MLR, M (Q, Q) | 0.24 (0.18, 0.35) | 0.24 (0.18, 0.35) | 0.24 (0.17, 0.36) | Z=0.498 | 0.619 |
| MPV/PLT, M (Q, Q) | 0.04 (0.03, 0.06) | 0.04 (0.03, 0.06) | 0.04 (0.03, 0.06) | Z=−0.179 | 0.858 |
| FAR, M (Q, Q) | 0.07 (0.06, 0.09) | 0.07 (0.06, 0.09) | 0.07 (0.06, 0.09) | Z=0.849 | 0.396 |
| PNI, Mean±SD | 416.26±49.03 | 417.01±47.83 | 414.50±51.76 | t=0.69 | 0.493 |
| SII, M (Q, Q) | 580.39 (372.65, 1056.61) | 581.29 (377.24, 1034.25) | 561.46 (356.53, 1110.03) | Z=0.091 | 0.927 |
| dNLR, M (Q, Q) | 1.86 (1.38, 2.68) | 1.84 (1.38, 2.61) | 1.92 (1.36, 2.96) | Z=0.630 | 0.529 |
| HPR, M (Q, Q) | 0.57 (0.42, 0.75) | 0.57 (0.42, 0.75) | 0.57 (0.42, 0.74) | Z=0.137 | 0.891 |
| Pathological diagnosis, n (%) | χ=0.034 | 0.854 | |||
| Colorectal adenoma | 325 (37.97) | 229 (38.17) | 96 (37.50) | ||
| CRC | 531 (62.03) | 371 (61.83) | 160 (62.50) | ||
| Grade, n (%) | χ=0.743 | 0.863 | |||
| Colorectal adenoma | 325 (37.97) | 229 (38.17) | 96 (37.50) | ||
| Poorly differentiated | 98 (11.45) | 65 (10.83) | 33 (12.89) | ||
| Moderately differentiated | 419 (48.95) | 296 (49.33) | 123 (48.05) | ||
| Well differentiated | 14 (1.64) | 10 (1.67) | 4 (1.56) | ||
| Stage, n (%) | χ=0.074 | 0.995 | |||
| Colorectal adenoma | 325 (37.97) | 229 (38.17) | 96 (37.50) | ||
| I CRC | 68 (7.94) | 48 (8.00) | 20 (7.81) | ||
| II CRC | 249 (29.09) | 173 (28.83) | 76 (29.69) | ||
| III CRC | 214 (25.00) | 150 (25.00) | 64 (25.00) | ||
| SD – standard deviation; M (Q, Q) – median (interquartile range); BMI – body mass index; Hb – hemoglobin; RBC – red blood cell; WBC – white blood cell; NEUT – neutrophil; LYM – lymphocyte; MONO – monocyte; PLT – platelet; MPV – mean platelet volume; PCT – plateletcrit (the product of PLT and MPV); RDW – red blood cell distribution width; PT – prothrombin time; APTT – activated partial thromboplastin time; TT – thrombin time; FIB – fibrinogen; CEA – carcinoembryonic antigen; GPT – glutamic pyruvic transaminase; GOT – glutamic oxaloacetic transaminase; TBil – total bilirubin; ALB – albumin; GLB – globulin; A/G – ALB-to-GLB ratio; BUN – blood urea nitrogen; Cr – creatinine; UA – uric acid; NLR – NEUT-to-LYM ratio; PLR – PLT-to-LYM ratio; MLR – MONO-to-LYM ratio; FAR – FIB-to-ALB ratio; PNI – 10×ALB+0.005×LYM; SII – systemic immune-inflammatory index; dNLR – NEUT/(WBC-NEUT); HPR – Hb-to-PLT ratio; CRC – colorectal cancer. | |||||