10 August 2022: Clinical Research
A Retrospective Study from a Single Center to Identify Hematological Factors that Distinguish Between Patients with Colorectal Carcinoma and Colorectal Adenoma
Jun Huang 12AE , Pingping Xu 3BCD , Youxiang Chen 4AE*DOI: 10.12659/MSM.936745
Med Sci Monit 2022; 28:e936745
Supplementary Table 3 Comparison of characteristics among CRC (poorly differentiated, moderately differentiated and well-differentiated) and colorectal adenoma in the training set.
| Characteristic | Total (n=600) | Groups | Statistics | P | ||
|---|---|---|---|---|---|---|
| Colorectal adenoma (n=229) | Poorly differentiated (n=65) | Moderately and well-differentiated (n=306) | ||||
| Gender, n (%) | χ=1.579 | 0.454 | ||||
| Male | 356 (59.33) | 142 (62.01) | 35 (53.85) | 179 (58.50) | ||
| Female | 244 (40.67) | 87 (37.99) | 30 (46.15) | 127 (41.50) | ||
| Age, years, Mean±SD | 56.16±12.43 | 56.78±11.70 | 57.00±13.51 | 55.52±12.73 | F=0.840 | 0.432 |
| BMI, kg/m, Mean±SD | 22.40±3.42 | 22.93±3.71 | 22.24±3.03 | 22.04±3.23 | F=4.588 | 0.011 |
| Diabetes, n (%) | χ=2.322 | 0.313 | ||||
| No | 575 (95.83) | 219 (95.63) | 60 (92.31) | 296 (96.73) | ||
| Yes | 25 (4.17) | 10 (4.37) | 5 (7.69) | 10 (3.27) | ||
| Inflammatory disease, n (%) | χ=7.535 | 0.023 | ||||
| No | 498 (83.00) | 195 (85.15) | 60 (92.31) | 243 (79.41) | ||
| Yes | 102 (17.00) | 34 (14.85) | 5 (7.69) | 63 (20.59) | ||
| Hb, g/L, Mean±SD | 125.48±24.67 | 137.79±19.88 | 116.89±22.00 | 118.09±24.79 | F=54.365 | |
| RBC, 10/L, Mean±SD | 4.24±0.63 | 4.49±0.55 | 4.03±0.65 | 4.10±0.63 | F=31.548 | |
| WBC, 10/L, M (Q, Q) | 5.91 (4.82, 7.22) | 5.84 (4.81, 6.68) | 6.35 (4.88, 7.79) | 6.01 (4.78, 7.58) | χ=4.856 | 0.088 |
| NEUT, 10/L, M (Q, Q) | 3.69 (2.89, 5.01) | 3.54 (2.82, 4.50) | 4.28 (3.28, 6.38) | 3.86 (2.88, 5.27) | χ=10.878 | 0.004 |
| LYM, 10/L, M (Q, Q) | 1.43 (1.09, 1.79) | 1.54 (1.24, 1.87) | 1.21 (0.80, 1.61) | 1.36 (1.07, 1.76) | χ=22.893 | |
| MONO, 10/L, M (Q, Q) | 0.35 (0.26, 0.47) | 0.34 (0.27, 0.44) | 0.34 (0.21, 0.48) | 0.36 (0.27, 0.49) | χ=3.859 | 0.145 |
| PLT, 10/L, M (Q, Q) | 229.00 (181.00, 84.00) | 212.00 (173.00, 253.00) | 230.00 (177.00, 280.00) | 246.50 (190.00, 316.00) | χ=27.175 | |
| MPV, fL, Mean±SD | 10.20±1.49 | 10.55±1.44 | 9.96±1.42 | 9.99±1.49 | F=10.820 | |
| PCT, %, M (Q, Q) | 0.23 (0.19, 0.28) | 0.22 (0.18, 0.26) | 0.22 (0.18, 0.27) | 0.24 (0.20, 0.30) | χ=19.367 | |
| RDW, %, Mean±SD | 13.59±2.52 | 13.12±1.61 | 13.52±2.34 | 13.95±3.01 | F=7.266 | |
| PT, s, Mean±SD | 11.25±0.98 | 10.80±0.90 | 11.71±1.23 | 11.48±0.85 | F=44.481 | |
| APTT, s, Mean±SD | 26.83±4.18 | 26.28±3.40 | 27.85±5.32 | 27.02±4.40 | F=4.244 | 0.015 |
| TT, s, Mean±SD | 18.27±1.72 | 17.82±1.71 | 18.79±2.41 | 18.49±1.46 | F=13.933 | |
| FIB, g/L, Mean±SD | 3.06±0.84 | 2.79±0.71 | 3.36±0.83 | 3.20±0.87 | F=22.282 | |
| D-dimer, mg/L, M (Q, Q) | 0.31 (0.17, 0.62) | 0.26 (0.16, 0.50) | 0.36 (0.20, 0.95) | 0.36 (0.19, 0.69) | χ=11.271 | 0.004 |
| CEA, ng/mL, M (Q, Q) | 1.82 (0.90, 3.80) | 1.37 (0.74, 2.35) | 2.12 (0.97, 6.32) | 2.35 (1.10, 5.17) | χ=35.221 | |
| Carbohydrate antigen 199, U/mL, M (Q, Q) | 10.84 (6.89, 20.45) | 10.34 (6.50, 17.06) | 12.36 (7.59, 21.99) | 11.18 (6.95, 22.43) | χ=5.860 | 0.053 |
| Carbohydrate antigen 125, U/mL, M (Q, Q) | 8.60 (6.30, 12.50) | 8.60 (6.20, 11.80) | 8.40 (6.10, 13.80) | 8.65 (6.30, 12.70) | χ=0.925 | 0.630 |
| GPT, U/L, M (Q, Q) | 16.00 (11.00, 24.00) | 18.90 (14.00, 26.00) | 14.00 (10.00, 19.00) | 15.00 (11.00, 23.00) | χ=30.629 | |
| GOT, U/L, M (Q, Q) | 21.00 (17.00, 26.00) | 23.00 (19.00, 27.00) | 20.00 (17.00, 25.00) | 20.00 (16.00, 25.00) | χ=22.080 | |
| TBil, μmol/L, M (Q, Q | 13.00 (9.30, 17.80) | 15.30 (11.40, 19.70) | 10.90 (8.50, 14.50) | 11.90 (8.30, 16.10) | χ=40.947 | |
| ALB+GLB, g/L, Mean±SD | 66.72±7.47 | 69.57±6.86 | 64.71±7.69 | 65.01±7.21 | F=29.651 | |
| ALB, g/L, Mean±SD | 41.70±4.78 | 42.38±4.21 | 41.23±5.35 | 41.29±5.01 | F=3.811 | 0.023 |
| GLB, g/L, Mean±SD | 25.02±4.60 | 27.19±4.80 | 23.48±4.15 | 23.72±3.87 | F=47.653 | |
| A/G, Mean±SD | 17.13±3.23 | 16.04±3.09 | 17.96±3.20 | 17.77±3.12 | F=22.772 | |
| BUN, mmol/L, M (Q, Q) | 4.80 (3.75, 5.80) | 5.20 (4.30, 6.20) | 4.60 (3.30, 5.40) | 4.50 (3.40, 5.70) | χ=36.821 | |
| Cr, μmol/L, M (Q, Q) | 71.00 (61.00, 84.00) | 73.00 (62.00, 86.00) | 74.00 (63.00, 83.00) | 69.50 (60.00, 84.00) | χ=3.604 | 0.165 |
| UA, μmol/L, M (Q, Q) | 286.00 (220.00, 360.00) | 325.00 (258.00, 391.00) | 271.00 (225.00, 364.00) | 258.00 (205.00, 324.00) | χ=48.833 | |
| NLR, M (Q, Q) | 2.55 (1.81, 3.95) | 2.22 (1.72, 3.08) | 3.72 (2.36, 5.65) | 2.68 (1.84, 4.28) | χ=30.638 | |
| PLR, M (Q, Q) | 156.44 (116.62, 229.85) | 136.30 (106.14, 174.32) | 187.41 (137.18, 252.66) | 169.92 (124.12, 269.23) | χ=42.616 | |
| MLR, M (Q, Q) | 0.24 (0.18, 0.35) | 0.21 (0.18, 0.30) | 0.25 (0.19, 0.40) | 0.26 (0.18, 0.38) | χ=9.869 | 0.007 |
| MPV/PLT, M (Q, Q) | 4.39 (3.37, 5.96) | 4.85 (3.83, 6.20) | 4.25 (3.25, 6.14) | 3.99 (2.93, 5.65) | χ=29.131 | |
| FAR, M (Q, Q) | 6.92 (5.87, 8.55) | 6.23 (5.43, 7.47) | 8.10 (6.60, 9.37) | 7.40 (6.22, 9.16) | χ=54.759 | |
| PNI, Mean±SD | 417.01±47.83 | 423.84±42.09 | 412.33±53.45 | 412.90±50.13 | F=3.811 | 0.023 |
| SII, M (Q, Q) | 581.29 (377.24, 1034.25) | 472.22 (339.95, 698.73) | 916.97 (510.66, 1364.54) | 636.51 (399.65, 1308.46) | χ=39.079 | |
| dNLR, M (Q, Q) | 1.84 (1.38, 2.61) | 1.73 (1.35, 2.15) | 2.46 (1.71, 3.60) | 1.93 (1.39, 2.85) | χ=26.104 | |
| HPR, M (Q, Q) | 0.57 (0.42, 0.75) | 0.67 (0.53, 0.81) | 0.52 (0.40, 0.75) | 0.50 (0.33, 0.69) | χ=61.731 | |
| SD – standard deviation; M (Q1, Q3) – median (interquartile range); BMI – body mass index; Hb – hemoglobin; RBC – red blood cell; WBC – white blood cell; NEUT – neutrophil; LYM – lymphocyte; MONO – monocyte; PLT – platelet; MPV – mean platelet volume; PCT – plateletcrit (the product of PLT and MPV); RDW – red blood cell distribution width; PT – prothrombin time; APTT – activated partial thromboplastin time; TT – thrombin time; FIB – fibrinogen; CEA – carcinoembryonic antigen; GPT – glutamic pyruvic transaminase; GOT – glutamic oxaloacetic transaminase; TBil – total bilirubin; ALB – albumin; GLB – globulin; A/G – ALB-to-GLB ratio; BUN – blood urea nitrogen; Cr – creatinine; UA – uric acid; NLR – NEUT-to-LYM ratio; PLR – PLT-to-LYM ratio; MLR – MONO-to-LYM ratio; FAR – FIB-to-ALB ratio; PNI – 10×ALB+0.005×LYM; SII – systemic immune-inflammatory index; dNLR – NEUT/(WBC-NEUT); HPR – Hb-to-PLT ratio. | ||||||