10 August 2022 : Clinical Research
A Retrospective Study from a Single Center to Identify Hematological Factors that Distinguish Between Patients with Colorectal Carcinoma and Colorectal Adenoma
Jun Huang12AE, Pingping Xu3BCD, Youxiang Chen4AE*DOI: 10.12659/MSM.936745
Med Sci Monit 2022; 28:e936745
Table 2 Comparison of characteristics between colorectal adenoma and CRC in the training set.
| Characteristic | Total (n=600) | Groups | Statistics | P | |
|---|---|---|---|---|---|
| Colorectal adenoma (n=229) | CRC (n=371) | ||||
| Gender, n (%) | χ=1.099 | 0.295 | |||
| Male | 356 (59.33) | 142 (62.01) | 214 (57.68) | ||
| Female | 244 (40.67) | 87 (37.99) | 157 (42.32) | ||
| Age, years, Mean±SD | 56.16±12.43 | 56.78±11.70 | 55.78±12.86 | t=0.960 | 0.338 |
| BMI, kg/m, Mean±SD | 22.40±3.42 | 22.93±3.71 | 22.08±3.19 | t=2.900 | 0.004 |
| Diabetes, n (%) | χ=0.037 | 0.847 | |||
| No | 575 (95.83) | 219 (95.63) | 356 (95.96) | ||
| Yes | 25 (4.17) | 10 (4.37) | 15 (4.04) | ||
| Inflammatory disease, n (%) | χ=1.216 | 0.270 | |||
| No | 498 (83.00) | 195 (85.15) | 303 (81.67) | ||
| Yes | 102 (17.00) | 34 (14.85) | 68 (18.33) | ||
| Hb, g/L, Mean±SD | 125.48±24.67 | 137.79±19.88 | 117.88±24.30 | t=10.930 | <0.001 |
| RBC, 10/L, Mean±SD | 4.24±0.63 | 4.49±0.55 | 4.09±0.63 | t=8.150 | <0.001 |
| WBC, 10/L, M (Q, Q) | 5.91 (4.82, 7.22) | 5.84 (4.81, 6.68) | 6.04 (4.82, 7.67) | Z=−2.076 | 0.038 |
| NEUT, 10/L, M (Q, Q) | 3.69 (2.89, 5.01) | 3.54 (2.82, 4.50) | 3.92 (2.92, 5.56) | Z=−2.879 | 0.004 |
| LYM, 10/L, M (Q, Q) | 1.43 (1.09, 1.79) | 1.54 (1.24, 1.87) | 1.33 (1.03, 1.72) | Z=4.050 | <0.001 |
| MONO, 10/L, M (Q, Q) | 0.35 (0.26, 0.47) | 0.34 (0.27, 0.44) | 0.35 (0.25, 0.49) | Z=−1.121 | 0.262 |
| PLT, 10/L, M (Q, Q) | 229.00 (181.00, 284.00) | 212.00 (173.00, 253.00) | 243.00 (187.00, 305.00) | Z=−4.912 | <0.001 |
| MPV, fL, Mean±SD | 10.20±1.49 | 10.55±1.44 | 9.98±1.48 | t=4.650 | <0.001 |
| PCT, %, M (Q, Q) | 0.23 (0.19, 0.28) | 0.22 (0.18, 0.26) | 0.24 (0.20, 0.29) | Z=−3.786 | <0.001 |
| RDW, %, Mean±SD | 13.59±2.52 | 13.12±1.61 | 13.87±2.91 | t=−4.080 | <0.001 |
| PT, s, Mean±SD | 11.25±0.98 | 10.80±0.90 | 11.52±0.93 | t=−9.220 | <0.001 |
| APTT, s, Mean±SD | 26.83±4.18 | 26.28±3.40 | 27.16±4.57 | t=−2.690 | 0.007 |
| TT, s, Mean±SD | 18.27±1.72 | 17.82±1.71 | 18.54±1.67 | t=−5.110 | <0.001 |
| FIB, g/L, Mean±SD | 3.06±0.84 | 2.79±0.71 | 3.23±0.87 | t=−6.840 | <0.001 |
| D-dimer, mg/L, M (Q, Q) | 0.31 (0.17, 0.62) | 0.26 (0.16, 0.50) | 0.36 (0.19, 0.71) | Z=−3.344 | <0.001 |
| CEA, ng/mL, M (Q, Q) | 1.82 (0.90, 3.80) | 1.37 (0.74, 2.35) | 2.33 (1.09, 5.31) | Z=−5.931 | <0.001 |
| Carbohydrate antigen 199, U/mL, M (Q, Q) | 10.84 (6.89, 20.45) | 10.34 (6.50, 17.06) | 11.30 (6.99, 22.43) | Z=−2.280 | 0.023 |
| Carbohydrate antigen 125, U/mL, M (Q, Q) | 8.60 (6.30, 12.50) | 8.60 (6.20, 11.80) | 8.50 (6.30, 13.00) | Z=−0.961 | 0.336 |
| GPT, U/L, M (Q, Q) | 16.00 (11.00, 24.00) | 18.90 (14.00, 26.00) | 14.00 (10.00, 22.00) | Z=5.241 | <0.001 |
| GOT, U/L, M (Q, Q) | 21.00 (17.00, 26.00) | 23.00 (19.00, 27.00) | 20.00 (16.00, 25.00) | Z=4.688 | <0.001 |
| TBil, μmol/L, M (Q, Q) | 13.00 (9.30, 17.80) | 15.30 (11.40, 19.70) | 11.70 (8.40, 16.10) | Z=6.389 | <0.001 |
| ALB+GLB, g/L, Mean±SD | 66.72±7.47 | 69.57±6.86 | 64.96±7.29 | t=7.700 | <0.001 |
| ALB, g/L, Mean±SD | 41.70±4.78 | 42.38±4.21 | 41.28±5.07 | t=2.880 | 0.004 |
| GLB, g/L, Mean±SD | 25.02±4.60 | 27.19±4.80 | 23.68±3.92 | t=9.310 | <0.001 |
| A/G, Mean±SD | 1.71±0.32 | 1.60±0.31 | 1.78±0.31 | t=−6.740 | <0.001 |
| BUN, mmol/L, M (Q, Q) | 4.80 (3.75, 5.80) | 5.20 (4.30, 6.20) | 4.50 (3.30, 5.60) | Z=6.065 | <0.001 |
| Cr, μmol/L, M (Q, Q) | 71.00 (61.00, 84.00) | 73.00 (62.00, 86.00) | 70.00 (60.00, 84.00) | Z=1.660 | 0.097 |
| UA, μmol/L, M (Q, Q) | 286.00 (220.00, 360.00) | 325.00 (258.00, 391.00) | 260.00 (207.00, 333.00) | Z=6.864 | <0.001 |
| NLR, M (Q, Q) | 2.55 (1.81, 3.95) | 2.22 (1.72, 3.08) | 2.85 (1.93, 4.50) | Z=−4.693 | <0.001 |
| PLR, M (Q, Q) | 156.44 (116.62, 229.85) | 136.30 (106.14, 174.32) | 176.36 (126.70, 264.58) | Z=−6.442 | <0.001 |
| MLR, M (Q, Q) | 0.24 (0.18, 0.35) | 0.21 (0.18, 0.30) | 0.26 (0.18, 0.38) | Z=−3.132 | 0.002 |
| MPV/PLT, M (Q, Q) | 0.04 (0.03, 0.06) | 0.05 (0.04, 0.06) | 0.04 (0.03, 0.06) | Z=5.243 | <0.001 |
| FAR, M (Q, Q) | 0.07 (0.06, 0.09) | 0.06 (0.05, 0.07) | 0.07 (0.06, 0.09) | Z=−7.222 | <0.001 |
| PNI, Mean±SD | 417.01±47.83 | 423.84±42.09 | 412.80±50.66 | t=2.880 | 0.004 |
| SII, M (Q, Q) | 581.29 (377.24, 1034.25) | 472.22 (339.95, 698.73) | 675.76 (417.75, 1325.62) | Z=−5.985 | <0.001 |
| dNLR, M (Q, Q) | 1.84 (1.38, 2.61) | 1.73 (1.35, 2.15) | 1.99 (1.42, 2.96) | Z=−4.042 | <0.001 |
| HPR, M (Q, Q) | 0.57 (0.42, 0.75) | 0.67 (0.53, 0.81) | 0.50 (0.34, 0.70) | Z=7.778 | <0.001 |
| SD – standard deviation; M (Q, Q) – median (interquartile range); BMI – body mass index; Hb – hemoglobin; RBC – red blood cell; WBC – white blood cell; NEUT – neutrophil; LYM – lymphocyte; MONO – monocyte; PLT – platelet; MPV – mean platelet volume; PCT – plateletcrit (the product of PLT and MPV); RDW – red blood cell distribution width; PT – prothrombin time; APTT – activated partial thromboplastin time; TT – thrombin time; FIB – fibrinogen; CEA – carcinoembryonic antigen; GPT – glutamic pyruvic transaminase; GOT – glutamic oxaloacetic transaminase; TBil – total bilirubin; ALB – albumin; GLB – globulin; A/G – ALB-to-GLB ratio; BUN – blood urea nitrogen; Cr – creatinine; UA – uric acid; NLR – NEUT-to-LYM ratio; PLR – PLT-to-LYM ratio; MLR – MONO-to-LYM ratio; FAR – FIB-to-ALB ratio; PNI – 10×ALB+0.005×LYM; SII – systemic immune-inflammatory index; dNLR – NEUT/(WBC-NEUT); HPR – Hb-to-PLT ratio; CRC – colorectal cancer. | |||||