10 August 2022: Clinical Research
A Retrospective Study from a Single Center to Identify Hematological Factors that Distinguish Between Patients with Colorectal Carcinoma and Colorectal Adenoma
Jun Huang 12AE , Pingping Xu 3BCD , Youxiang Chen 4AE*DOI: 10.12659/MSM.936745
Med Sci Monit 2022; 28:e936745
Table 4 Diagnostic indicators for CRC patients using the multivariate logistic regression model in participants grouped into stage I, II, and III CRC and colorectal adenoma.
| Variables | Model | β | SE | Wald | P | OR | 95% CI | |
|---|---|---|---|---|---|---|---|---|
| Lower | Upper | |||||||
| PT | Colorectal adenoma & stage III CRC | 0.758 | 0.152 | 24.820 | 2.133 | 1.583 | 2.874 | |
| Colorectal adenoma & stage II CRC | 0.702 | 0.149 | 22.157 | 2.019 | 1.507 | 2.704 | ||
| Colorectal adenoma & stage I CRC | 0.617 | 0.198 | 9.734 | 0.002 | 1.853 | 1.258 | 2.731 | |
| TT | Colorectal adenoma & stage III CRC | 0.526 | 0.085 | 38.103 | 1.432 | 2.000 | 1.432 | |
| Colorectal adenoma & stage II CRC | 0.408 | 0.085 | 23.212 | 1.503 | 1.274 | 1.774 | ||
| Colorectal adenoma & stage I CRC | 0.261 | 0.113 | 5.324 | 0.021 | 1.298 | 1.040 | 1.620 | |
| CEA | Colorectal adenoma & stage III CRC | 0.073 | 0.027 | 7.444 | 0.006 | 1.075 | 1.021 | 1.133 |
| Colorectal adenoma & stage II CRC | 0.057 | 0.027 | 4.508 | 0.034 | 1.058 | 1.004 | 1.115 | |
| Colorectal adenoma & stage I CRC | −0.074 | 0.067 | 1.196 | 0.274 | 0.929 | 0.814 | 1.060 | |
| A/G | Colorectal adenoma & stage III CRC | 0.331 | 0.049 | 46.078 | 1.392 | 1.265 | 1.531 | |
| Colorectal adenoma & stage II CRC | 0.327 | 0.047 | 47.848 | 1.386 | 1.264 | 1.521 | ||
| Colorectal adenoma & stage I CRC | 0.303 | 0.060 | 25.932 | 1.354 | 1.205 | 1.522 | ||
| FAR | Colorectal adenoma & stage III CRC | 0.433 | 0.073 | 35.557 | 1.542 | 1.338 | 1.779 | |
| Colorectal adenoma & stage II CRC | 0.482 | 0.071 | 46.046 | 1.619 | 1.409 | 1.861 | ||
| Colorectal adenoma & stage I CRC | 0.199 | 0.102 | 3.782 | 0.052 | 1.220 | 0.998 | 1.490 | |
| HPR | Colorectal adenoma & stage III CRC | −2.337 | 0.531 | 19.344 | 0.097 | 0.034 | 0.274 | |
| Colorectal adenoma & stage II CRC | −2.830 | 0.529 | 28.567 | 0.059 | 0.021 | 0.167 | ||
| Colorectal adenoma & stage I CRC | −0.774 | 0.633 | 1.497 | 0.221 | 0.461 | 0.133 | 1.594 | |
| OR – odds ratio; CI – confidence interval; SE – standard error; β – beta coefficient; Wald – Wald Chi-square; PT – prothrombin time; TT – thrombin time; CEA – carcinoembryonic antigen; A/G – albumin-globulin ratio; FAR – fibrinogen-albumin ratio; HPR – hemoglobin-platelet ratio; CRC – colorectal cancer. | ||||||||