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10 August 2022: Clinical Research

A Retrospective Study from a Single Center to Identify Hematological Factors that Distinguish Between Patients with Colorectal Carcinoma and Colorectal Adenoma

Jun Huang 12AE , Pingping Xu 3BCD , Youxiang Chen 4AE*

DOI: 10.12659/MSM.936745

Med Sci Monit 2022; 28:e936745

Table 7 Performance of the prediction model in patients with or without inflammatory disease in the testing set.

Patients grouped into CRC and colorectal adenomaPatients grouped into stage I, II, and III CRC and colorectal adenomaPatients grouped into poorly differentiated CRC, moderately and well-differentiated CRC, and colorectal adenoma
With inflammatory diseaseWithout inflammatory diseaseWith inflammatory diseaseWithout inflammatory diseaseWith inflammatory diseaseWithout inflammatory disease
AUC (95% CI)0.879 (0.760–0.997)0.835 (0.741–0.928)0.860 (0.799–0.921)0.814 (0.781–0.846)0.851 (0.776–0.926)0.827 (0.792–0.861)
Accuracy (95% CI)0.854 (0.722–0.939)0.764 (0.649–0.856)0.740 (0.678–0.802)0.720 (0.689–0.750)0.833 (0.772–0.894)0.790 (0.758–0.822)
Sensitivity (95% CI)0.879 (0.767–0.990)0.829 (0.714–0.944)0.875 (0.781–0.969)0.774 (0.717–0.831)0.729 (0.603–0.855)0.702 (0.640–0.764)
Specificity (95% CI)0.800 (0.598–1.002)0.677 (0.513–0.842)0.694 (0.619–0.770)0.702 (0.666–0.738)0.885 (0.822–0.949)0.834 (0.798–0.870)
PPV (95% CI)0.906 (0.805–0.999)0.773 (0.649–0.897)0.488 (0.383–0.594)0.464 (0.412–0.516)0.761 (0.638–0.884)0.679 (0.617–0.741)
NPV (95% CI)0.750 (0.538–0.962)0.750 (0.590–0.910)0.943 (0.899–0.987)0.903 (0.877–0.929)0.867 (0.800–0.935)0.848 (0.814–0.883)
AUC – area under the curve; CI – confidence interval; PPV – positive predictive value; NPV – negative predictive value; CRC – colorectal cancer.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750