10 August 2022>: Clinical Research
A Retrospective Study from a Single Center to Identify Hematological Factors that Distinguish Between Patients with Colorectal Carcinoma and Colorectal Adenoma
Jun Huang 12AE , Pingping Xu 3BCD , Youxiang Chen 4AE*DOI: 10.12659/MSM.936745
Med Sci Monit 2022; 28:e936745
Table 7 Performance of the prediction model in patients with or without inflammatory disease in the testing set.
Patients grouped into CRC and colorectal adenoma | Patients grouped into stage I, II, and III CRC and colorectal adenoma | Patients grouped into poorly differentiated CRC, moderately and well-differentiated CRC, and colorectal adenoma | ||||
---|---|---|---|---|---|---|
With inflammatory disease | Without inflammatory disease | With inflammatory disease | Without inflammatory disease | With inflammatory disease | Without inflammatory disease | |
AUC (95% CI) | 0.879 (0.760–0.997) | 0.835 (0.741–0.928) | 0.860 (0.799–0.921) | 0.814 (0.781–0.846) | 0.851 (0.776–0.926) | 0.827 (0.792–0.861) |
Accuracy (95% CI) | 0.854 (0.722–0.939) | 0.764 (0.649–0.856) | 0.740 (0.678–0.802) | 0.720 (0.689–0.750) | 0.833 (0.772–0.894) | 0.790 (0.758–0.822) |
Sensitivity (95% CI) | 0.879 (0.767–0.990) | 0.829 (0.714–0.944) | 0.875 (0.781–0.969) | 0.774 (0.717–0.831) | 0.729 (0.603–0.855) | 0.702 (0.640–0.764) |
Specificity (95% CI) | 0.800 (0.598–1.002) | 0.677 (0.513–0.842) | 0.694 (0.619–0.770) | 0.702 (0.666–0.738) | 0.885 (0.822–0.949) | 0.834 (0.798–0.870) |
PPV (95% CI) | 0.906 (0.805–0.999) | 0.773 (0.649–0.897) | 0.488 (0.383–0.594) | 0.464 (0.412–0.516) | 0.761 (0.638–0.884) | 0.679 (0.617–0.741) |
NPV (95% CI) | 0.750 (0.538–0.962) | 0.750 (0.590–0.910) | 0.943 (0.899–0.987) | 0.903 (0.877–0.929) | 0.867 (0.800–0.935) | 0.848 (0.814–0.883) |
AUC – area under the curve; CI – confidence interval; PPV – positive predictive value; NPV – negative predictive value; CRC – colorectal cancer. |