10 August 2022: Clinical Research
A Retrospective Study from a Single Center to Identify Hematological Factors that Distinguish Between Patients with Colorectal Carcinoma and Colorectal Adenoma
Jun Huang 12AE , Pingping Xu 3BCD , Youxiang Chen 4AE*DOI: 10.12659/MSM.936745
Med Sci Monit 2022; 28:e936745
Supplementary Table 2 Comparison of characteristics among CRC stage I, II, III and colorectal adenoma in the training set.
| Characteristic | Total (n=600) | Groups | Statistics | P | |||
|---|---|---|---|---|---|---|---|
| Colorectal adenoma (n=229) | Stage I (n=48) | Stage II (n=173) | Stage III (n=150) | ||||
| Gender, n (%) | χ=1.639 | 0.650 | |||||
| Male | 356 (59.33) | 142 (62.01) | 30 (62.50) | 99 (57.23) | 85 (56.67) | ||
| Female | 244 (40.67) | 87 (37.99) | 18 (37.50) | 74 (42.77) | 65 (43.33) | ||
| Age, years, Mean±SD | 56.16±12.43 | 56.78±11.70 | 55.98±11.68 | 57.14±13.05 | 54.15±12.91 | F=1.871 | 0.133 |
| BMI, kg/m, Mean±SD | 22.40±3.42 | 22.93±3.71 | 22.31±3.24 | 21.90±3.06 | 22.20±3.34 | F=3.289 | 0.020 |
| Diabetes, n (%) | χ=2.634 | 0.452 | |||||
| No | 575 (95.83) | 219 (95.63) | 47 (97.92) | 163 (94.22) | 146 (97.33) | ||
| Yes | 25 (4.17) | 10 (4.37) | 1 (2.08) | 10 (5.78) | 4 (2.67) | ||
| Inflammatory disease, n (%) | χ=2.058 | 0.560 | |||||
| No | 498 (83.00) | 195 (85.15) | 37 (77.08) | 142 (82.08) | 124 (82.67) | ||
| Yes | 102 (17.00) | 34 (14.85) | 11 (22.92) | 31 (17.92) | 26 (17.33) | ||
| Hb, g/L, Mean±SD | 125.48±24.67 | 137.79±19.88 | 125.35±21.08 | 115.50±25.08 | 118.24±23.99 | F=38.961 | |
| RBC, 10/L, Mean±SD | 4.24±0.63 | 4.49±0.55 | 4.08±0.58 | 4.07±0.61 | 4.11±0.67 | F=20.940 | |
| WBC, 10/L, M (Q, Q) | 5.91 (4.82, 7.22) | 5.84 (4.81, 6.68) | 5.54 (4.73, 7.05) | 6.21 (4.86, 7.72) | 6.00 (4.78, 7.75) | χ=6.071 | 0.108 |
| NEUT, 10/L, M (Q, Q) | 3.69 (2.89, 5.01) | 3.54 (2.82, 4.50) | 3.39 (2.94, 4.77) | 4.03 (2.92, 5.60) | 4.01 (2.90, 5.62) | χ=10.729 | 0.013 |
| LYM, 10/L, M (Q, Q) | 1.43 (1.09, 1.79) | 1.54 (1.24, 1.87) | 1.46 (1.05, 1.80) | 1.35 (1.08, 1.74) | 1.28 (1.01, 1.67) | χ=19.112 | |
| MONO, 10/L, M (Q, Q) | 0.35 (0.26, 0.47) | 0.34 (0.27, 0.44) | 0.35 (0.26, 0.45) | 0.35 (0.25, 0.49) | 0.36 (0.25, 0.49) | χ=1.896 | 0.594 |
| PLT, 109/L, M (Q, Q) | 229.00 (181.00, 284.00) | 212.00 (173.00, 253.00) | 210.00 (173.00, 273.00) | 260.00 (197.00, 325.00) | 241.50 (186.00, 292.00) | χ=32.943 | |
| MPV, fL, Mean±SD | 10.20±1.49 | 10.55±1.44 | 10.32±1.53 | 9.85±1.47 | 10.03±1.45 | F=8.670 | |
| PCT, %, M (Q, Q) | 0.23 (0.19, 0.28) | 0.22 (0.18, 0.26) | 0.22 (0.18, 0.26) | 0.24 (0.20, 0.30) | 0.24 (0.19, 0.28) | χ=20.671 | |
| RDW, %, Mean±SD | 13.59±2.52 | 13.12±1.61 | 13.06±1.69 | 14.19±3.26 | 13.77±2.73 | F=7.084 | |
| PT, s, Mean±SD | 11.25±0.98 | 10.80±0.90 | 11.31±0.97 | 11.55±0.86 | 11.55±1.00 | F=29.317 | |
| APTT, s, Mean±SD | 26.83±4.18 | 26.28±3.40 | 27.01±5.37 | 27.21±4.27 | 27.17±4.67 | F=2.131 | 0.095 |
| TT, s, Mean±SD | 18.27±1.72 | 17.82±1.71 | 18.38±1.00 | 18.36±1.58 | 18.80±1.89 | F=10.820 | |
| FIB, g/L, Mean±SD | 3.06±0.84 | 2.79±0.71 | 2.80±0.60 | 3.40±0.88 | 3.17±0.87 | F=22.296 | |
| D-dimer, mg/L, M (Q, Q) | 0.31 (0.17, 0.62) | 0.26 (0.16, 0.50) | 0.24 (0.17, 0.46) | 0.43 (0.20, 0.84) | 0.36 (0.18, 0.69) | χ=19.280 | |
| CEA, ng/mL, M (Q, Q) | 1.82 (0.90, 3.80) | 1.37 (0.74, 2.35) | 1.25 (0.59, 2.43) | 2.21 (1.06, 4.66) | 3.19 (1.25, 7.82) | χ=58.969 | |
| Carbohydrate antigen 199, U/mL, M (Q1, Q3) | 10.84 (6.89, 20.45) | 10.34 (6.50, 17.06) | 9.87 (7.86, 15.02) | 10.21 (6.11, 20.35) | 15.16 (7.73, 32.82) | χ=19.579 | |
| Carbohydrate antigen 125, U/mL, M (Q, Q) | 8.60 (6.30, 12.50) | 8.60 (6.20, 11.80) | 8.85 (6.45, 15.10) | 8.30 (6.20, 12.70) | 8.50 (6.40, 13.00) | χ=1.198 | 0.754 |
| GPT, U/L, M (Q, Q) | 16.00 (11.00, 24.00) | 18.90 (14.00, 26.00) | 14.00 (11.50, 22.00) | 14.00 (10.00, 22.00) | 16.00 (11.00, 22.00) | χ=28.445 | |
| GOT, U/L, M (Q, Q) | 21.00 (17.00, 26.00) | 23.00 (19.00, 27.00) | 19.00 (16.00, 25.00) | 19.00 (16.00, 25.00) | 20.50 (16.00, 26.00) | χ=23.232 | |
| TBil, μmol/L, M (Q, Q) | 13.00 (9.30, 17.80) | 15.30 (11.40, 19.70) | 12.60 (8.40, 17.45) | 11.50 (8.30, 15.40) | 11.20 (8.50, 17.00) | χ=43.204 | |
| ALB+GLB, g/L, Mean±SD | 66.72±7.47 | 69.57±6.86 | 65.23±6.20 | 65.36±7.36 | 64.42±7.53 | F=20.237 | |
| ALB, g/L, Mean±SD | 41.70±4.78 | 42.38±4.21 | 42.09±4.37 | 41.32±5.07 | 40.97±5.26 | F=3.225 | 0.022 |
| GLB, g/L, Mean±SD | 25.02±4.60 | 27.19±4.80 | 23.14±3.47 | 24.03±3.90 | 23.45±4.07 | F=32.578 | |
| A/G, Mean±SD | 17.13±3.23 | 16.04±3.09 | 18.55±3.07 | 17.55±3.04 | 17.86±3.22 | F=16.516 | |
| BUN, mmol/L, M (Q, Q) | 4.80 (3.75, 5.80) | 5.20 (4.30, 6.20) | 4.15 (3.30, 5.30) | 4.70 (3.50, 5.80) | 4.40 (3.20, 5.40) | χ=42.558 | |
| Cr, μmol/L, M (Q, Q) | 71.00 (61.00, 84.00) | 73.00 (62.00, 86.00) | 68.00 (62.00, 76.00) | 72.00 (61.00, 86.00) | 70.00 (59.00, 82.00) | χ=5.528 | 0.137 |
| UA, μmol/L, M (Q, Q) | 286.00 (220.00, 360.00) | 325.00 (258.00, 391.00) | 268.00 (215.00, 333.00) | 258.00 (207.00, 336.00) | 260.00 (200.00, 323.00) | χ=47.807 | |
| NLR, M (Q, Q) | 2.55 (1.81, 3.95) | 2.22 (1.72, 3.08) | 2.33 (1.76, 3.54) | 2.85 (1.93, 4.31) | 2.95 (2.03, 4.67) | χ=25.636 | |
| PLR, M (Q, Q) | 156.44 (116.62, 229.85) | 136.30 (106.14, 174.32) | 141.73 (111.07, 234.94) | 187.38 (130.72, 264.84) | 180.18 (128.30, 269.23) | χ=48.147 | |
| MLR, M (Q, Q) | 0.24 (0.18, 0.35) | 0.21 (0.18, 0.30) | 0.24 (0.17, 0.34) | 0.25 (0.17, 0.39) | 0.27 (0.19, 0.38) | χ=11.564 | 0.009 |
| MPV/PLT, M (Q, Q) | 4.39 (3.37, 5.96) | 4.85 (3.83, 6.20) | 4.64 (3.55, 6.43) | 3.81 (2.83, 5.33) | 3.97 (3.28, 5.83) | χ=37.396 | |
| FAR, M (Q, Q) | 6.92 (5.87, 8.55) | 6.23 (5.43, 7.47) | 6.30 (5.66, 7.51) | 7.78 (6.58, 9.72) | 7.47 (6.26, 9.39) | χ=70.445 | |
| PNI, Mean±SD | 417.01±47.83 | 423.84±42.09 | 420.92±43.66 | 413.22±50.71 | 409.71±52.64 | F=3.225 | 0.022 |
| SII, M (Q, Q) | 581.29 (377.24, 1034.25) | 472.22 (339.95, 698.73) | 473.36 (368.35, 832.25) | 689.45 (459.50, 1385.74) | 707.59 (382.92, 1357.32) | χ=43.260 | |
| dNLR, M (Q, Q) | 1.84 (1.38, 2.61) | 1.73 (1.35, 2.15) | 1.74 (1.30, 2.32) | 1.98 (1.45, 2.97) | 2.14 (1.46, 3.14) | χ=20.077 | |
| HPR, M (Q, Q) | 0.57 (0.42, 0.75) | 0.67 (0.53, 0.81) | 0.60 (0.41, 0.81) | 0.46 (0.33, 0.62) | 0.52 (0.33, 0.70) | χ=72.312 | |
| SD – standard deviation; M (Q1, Q3) – median (interquartile range); BMI – body mass index; Hb – hemoglobin; RBC – red blood cell; WBC – white blood cell; NEUT – neutrophil; LYM – lymphocyte; MONO – monocyte; PLT – platelet; MPV – mean platelet volume; PCT – plateletcrit (the product of PLT and MPV); RDW – red blood cell distribution width; PT – prothrombin time; APTT – activated partial thromboplastin time; TT – thrombin time; FIB – fibrinogen; CEA – carcinoembryonic antigen; GPT – glutamic pyruvic transaminase; GOT – glutamic oxaloacetic transaminase; TBil – total bilirubin; ALB – albumin; GLB – globulin; A/G – ALB-to-GLB ratio; BUN – blood urea nitrogen; Cr – creatinine; UA – uric acid; NLR – NEUT-to-LYM ratio; PLR – PLT-to-LYM ratio; MLR – MONO-to-LYM ratio; FAR – FIB-to-ALB ratio; PNI – 10×ALB+0.005×LYM; SII – systemic immune-inflammatory index; dNLR :– NEUT/(WBC-NEUT); HPR – Hb-to-PLT ratio. | |||||||