01 September 2022 : Clinical Research
High Level of Irisin as a Marker of Malnutrition in Head and Neck Cancer Patients Subjected to Radiotherapy
Iwona Homa-Mlak1ACDEF*, Radosław Mlak1ACDEF, Anna Brzozowska2BDF, Marcin Mazurek1CEF, Tomasz Powrózek1CDE, Monika Prendecka-Wróbel1CEF, Aneta Szudy-Szczyrek2ADE, Piotr Dreher3CEF, Katarzyna Kamińska4F, Teresa Małecka-Massalska1ACEF, Alicja Wójcik-Załuska5CEGDOI: 10.12659/MSM.936857
Med Sci Monit 2022; 28:e936857
Table 3 The relationship between factors reflecting malnutrition status and irisin level in HNC patients.
| Factor | Cases (n=50) | Irisin level median (95% CI) | p | |
|---|---|---|---|---|
| NRS-2002 | <3 | 34 (68%) | 1.18 (1.09–1.35) | 0.0004* |
| ≥3 | 16 (32%) | 1.57 (1.36–2.12) | ||
| SGA | A | 8 (16%) | 1.07 (0.70–1.29) | 0.0139* |
| B and C | 42 (84%) | 1.38 (1.23–1.51) | ||
| SGA | A and B | 32 (64%) | 1.23 (1.14–1.39) | 0.0630 |
| C | 18 (36%) | 1.45 (1.20–1.74) | ||
| BMI I (kg/m) | <18.5 | 5 (10%) | 2.53 (−) | 0.0585 |
| >18.5 | 45 (90%) | 1.33 (1.16–1.42) | ||
| BMI VII (kg/m) | <18.5 | 12 (24%) | 1.31 (1.14–2.40) | 0.3880 |
| >18.5 | 38 (76%) | 1.33 (1.16–1.43) | ||
| Total protein | Normal | 45 (90%) | 1.33 (1.18–1.45) | 0.9099 |
| Abnormal (lowered) | 5 (10%) | 1.27 (−) | ||
| Albumin | Normal | 12 (24%) | 1.28 (0.99–1.66) | 0.8380 |
| Abnormal (lowered) | 38 (76%) | 1.33 (1.17–1.43) | ||
| Transferrin | Norma | 41 (82%) | 1.33 (1.20–1.45) | 0.5034 |
| Abnormal (lowered) | 9 (18%) | 1.19 (0.98–1.56) | ||
| Parenteral nutrition | Yes | 8 (16%) | 1.56 (1.16–4.22) | 0.0416* |
| No | 42 (84%) | 1.27 (1.14–1.40) | ||
| Antibiotic | Yes | 14 (28%) | 1.31 (1.08–1.69) | 0.8628 |
| No | 36 (72%) | 1.36 (1.17–1.44) | ||
| * Statistically significant results. BMI – body mass index; NRS-2002 – Nutritional Risk Screening 2002; SGA – Subjective Global Assessment. | ||||