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01 September 2022: Clinical Research

High Level of Irisin as a Marker of Malnutrition in Head and Neck Cancer Patients Subjected to Radiotherapy

Iwona Homa-Mlak 1ACDEF* , Radosław Mlak 1ACDEF , Anna Brzozowska 2BDF , Marcin Mazurek 1CEF , Tomasz Powrózek 1CDF , Monika Prendecka-Wróbel 1CEF , Aneta Szudy-Szczyrek 2ADE , Piotr Dreher 3CEF , Katarzyna Kamińska 4F , Teresa Małecka-Massalska 1ACEF , Alicja Wójcik-Załuska 5CEG

DOI: 10.12659/MSM.936857

Med Sci Monit 2022; 28:e936857

Table 3 The relationship between factors reflecting malnutrition status and irisin level in HNC patients.

FactorCases (n=50)Irisin level median (95% CI)p
NRS-200234 (68%)1.18 (1.09–1.35)0.0004*
≥316 (32%)1.57 (1.36–2.12)
SGAA8 (16%)1.07 (0.70–1.29)0.0139*
B and C42 (84%)1.38 (1.23–1.51)
SGAA and B32 (64%)1.23 (1.14–1.39)0.0630
C18 (36%)1.45 (1.20–1.74)
BMI I (kg/m)5 (10%)2.53 (−)0.0585
>18.545 (90%)1.33 (1.16–1.42)
BMI VII (kg/m)12 (24%)1.31 (1.14–2.40)0.3880
>18.538 (76%)1.33 (1.16–1.43)
Total proteinNormal45 (90%)1.33 (1.18–1.45)0.9099
Abnormal (lowered)5 (10%)1.27 (−)
AlbuminNormal12 (24%)1.28 (0.99–1.66)0.8380
Abnormal (lowered)38 (76%)1.33 (1.17–1.43)
TransferrinNorma41 (82%)1.33 (1.20–1.45)0.5034
Abnormal (lowered)9 (18%)1.19 (0.98–1.56)
Parenteral nutritionYes8 (16%)1.56 (1.16–4.22)0.0416*
No42 (84%)1.27 (1.14–1.40)
AntibioticYes14 (28%)1.31 (1.08–1.69)0.8628
No36 (72%)1.36 (1.17–1.44)
* Statistically significant results.
BMI – body mass index; NRS-2002 – Nutritional Risk Screening 2002; SGA – Subjective Global Assessment.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750