27 July 2022 : Meta-Analysis
The Prognostic Value of Periostin Expression in Non-Small Cell Lung Cancer: A Meta-Analysis
Mengjie Li1234ABCDEFG, Guangzhi Ma1ABCDEF, Xuebing Li2ACFG*, Qinghua Zhou12ACFGDOI: 10.12659/MSM.936898
Med Sci Monit 2022; 28:e936898
Table 2 Meta-analyses of high periostin and survival of NSCLC patients.
| N of study | Model | HR (95% CI) | Log-rank p | Heterogeneity (P value, I2 (%)) | Conclusion | |
|---|---|---|---|---|---|---|
| Total PFS | 4 | Random | 1.296 (0.965–1.740) | 0.085 | 0.002, 80.3% | Negative |
| Total OS | 10 | Random | 1.761 (1.022–3.033) | 0.041 | 0.000, 76.0% | Positive |
| Chinese PFS | 2 | Random | 1.350 (0.687–2.651) | 0.384 | 0.011, 84.6% | Negative |
| Asian OS | 8 | Random | 2.052 (1.113–3.781) | 0.021 | 0.001, 72.1% | Positive |
| Japanese OS | 6 | Random | 1.903 (0.826–4.384) | 0.131 | 0.000, 77.8% | Negative |
| Chinese OS | 2 | Fixed | 2.274 (1.320–3.918) | 0.003 | 0.227, 31.6% | Positive |
| ELISA PFS | 2 | Random | 1.350 (0.687–2.651) | 0.384 | 0.011, 84.6% | Negative |
| IHC OS | 6 | Random | 1.426 (0.653–3.116) | 0.373 | 0.000, 82.0% | Negative |
| RP OS | 3 | Random | 1.873 (0.475–7.380) | 0.370 | 0.000, 90.1% | Negative |
| MM OS | 3 | Random | 1.055 (0.385–2.890) | 0.917 | 0.044, 67.9% | Negative |
| CI – confidence interval; ELISA – enzyme-linked immunosorbent assay; HR – hazard ratio; IHC – immunohistochemistry; MM – mouse monoclonal; N – number; OS – overall survival; PFS – progression-free survival; RP – rabbit polyclonal. | ||||||