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27 July 2022 : Meta-Analysis  

The Prognostic Value of Periostin Expression in Non-Small Cell Lung Cancer: A Meta-Analysis

Mengjie Li1234ABCDEFG, Guangzhi Ma1ABCDEF, Xuebing Li2ACFG*, Qinghua Zhou12ACFG

DOI: 10.12659/MSM.936898

Med Sci Monit 2022; 28:e936898

Table 2 Meta-analyses of high periostin and survival of NSCLC patients.

N of studyModelHR (95% CI)Log-rank pHeterogeneity (P value, I2 (%))Conclusion
Total PFS4Random1.296 (0.965–1.740)0.0850.002, 80.3%Negative
Total OS10Random1.761 (1.022–3.033)0.0410.000, 76.0%Positive
Chinese PFS2Random1.350 (0.687–2.651)0.3840.011, 84.6%Negative
Asian OS8Random2.052 (1.113–3.781)0.0210.001, 72.1%Positive
Japanese OS6Random1.903 (0.826–4.384)0.1310.000, 77.8%Negative
Chinese OS2Fixed2.274 (1.320–3.918)0.0030.227, 31.6%Positive
ELISA PFS2Random1.350 (0.687–2.651)0.3840.011, 84.6%Negative
IHC OS6Random1.426 (0.653–3.116)0.3730.000, 82.0%Negative
RP OS3Random1.873 (0.475–7.380)0.3700.000, 90.1%Negative
MM OS3Random1.055 (0.385–2.890)0.9170.044, 67.9%Negative
CI – confidence interval; ELISA – enzyme-linked immunosorbent assay; HR – hazard ratio; IHC – immunohistochemistry; MM – mouse monoclonal; N – number; OS – overall survival; PFS – progression-free survival; RP – rabbit polyclonal.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750