27 July 2022>: Meta-Analysis
The Prognostic Value of Periostin Expression in Non-Small Cell Lung Cancer: A Meta-Analysis
Mengjie Li 1234ABCDEFG* , Guangzhi Ma 1ABCDEF* , Xuebing Li 2ACFG* , Qinghua Zhou 12ACFG*DOI: 10.12659/MSM.936898
Med Sci Monit 2022; 28:e936898
Table 2 Meta-analyses of high periostin and survival of NSCLC patients.
N of study | Model | HR (95% CI) | Log-rank p | Heterogeneity (P value, I2 (%)) | Conclusion | |
---|---|---|---|---|---|---|
Total PFS | 4 | Random | 1.296 (0.965–1.740) | 0.085 | 0.002, 80.3% | Negative |
Total OS | 10 | Random | 1.761 (1.022–3.033) | 0.041 | 0.000, 76.0% | Positive |
Chinese PFS | 2 | Random | 1.350 (0.687–2.651) | 0.384 | 0.011, 84.6% | Negative |
Asian OS | 8 | Random | 2.052 (1.113–3.781) | 0.021 | 0.001, 72.1% | Positive |
Japanese OS | 6 | Random | 1.903 (0.826–4.384) | 0.131 | 0.000, 77.8% | Negative |
Chinese OS | 2 | Fixed | 2.274 (1.320–3.918) | 0.003 | 0.227, 31.6% | Positive |
ELISA PFS | 2 | Random | 1.350 (0.687–2.651) | 0.384 | 0.011, 84.6% | Negative |
IHC OS | 6 | Random | 1.426 (0.653–3.116) | 0.373 | 0.000, 82.0% | Negative |
RP OS | 3 | Random | 1.873 (0.475–7.380) | 0.370 | 0.000, 90.1% | Negative |
MM OS | 3 | Random | 1.055 (0.385–2.890) | 0.917 | 0.044, 67.9% | Negative |
CI – confidence interval; ELISA – enzyme-linked immunosorbent assay; HR – hazard ratio; IHC – immunohistochemistry; MM – mouse monoclonal; N – number; OS – overall survival; PFS – progression-free survival; RP – rabbit polyclonal. |