Retrospective Study from a Single Center to Identify Risk Factors Associated with Reinfection in Patients Undergoing 2-Stage Revision Surgery for Periprosthetic Joint Infection

Bingshi Zhang; Zeming Liu; Sikai Liu; Bo Liu; Mengnan Li; Wenao Li; Yongtai Han

doi:10.12659/MSM.936973

13 June 2022 : Database Analysis

Retrospective Study from a Single Center to Identify Risk Factors Associated with Reinfection in Patients Undergoing 2-Stage Revision Surgery for Periprosthetic Joint Infection

Bingshi Zhang^1ABCE, Zeming Liu^1CE, Sikai Liu^1BC, Bo Liu^1BC, Mengnan Li^1B, Wenao Li^1E, Yongtai Han^1ABCDE*

DOI: 10.12659/MSM.936973

Med Sci Monit 2022; 28:e936973

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Table 2 Results of hematological, bacteriological, and laboratory examinations of patients with periprosthetic joint infection undergoing 2-stage hip revision surgery.

Patient characteristics	Infection recurrence (n=25)	Infection nonrecurrence (n=330)	P
CRP (mg/L)	32.63±14.59	26.70±11.59	0.002^*
Albumin (g/L)	32.37±8.25	36.01±7.41	0.029^*
Globulin (g/L)	29.83±6.19	24.37±5.87	0.004^*
Albumin/globulin	1.12±0.29	1.49±0.36	<0.001^*
Glucose
<5.6	7	251	<0.001^#
5.6–11.2	8	46
>11.2	10	33
Hemoglobin (g/L)	119.56±19.31	121.72±17.68	0.827^*
ESR (mm/min)	52.54±11.53	50.71±16.37	0.392^*
Fibrinogen (g/L)	3.95±0.88	3.89±0.97	0.722^*
D-dimer (mg/ml)	0.91±0.37	0.86±0.32	0.109^*
Platelet count	341.70±99.65	327.23±85.82	0.510^*
MRI findings
Negative findings	2	157	<0.001^#
Only lamellated hyperintense synovitis	8	73
Only soft tissue edema	9	77
Lamellated hyperintense synovitis and soft tissue edema	6	23
Allogeneic blood transfusion
No	13	164	0.824^#
Yes	12	166
Infectious bacteria
Negative	4	58	<0.001^#
G+ bacteria	19	257
G− bacteria	2	15
Antibiotic-resistant bacteria
Yes	8	63	0.120^#
No	17	267
Antibiotics used regularly (≥3 weeks)
No	6	77	0.939^#
Yes	19	253
Time of remission (days)	28.04±10.36	26.14±11.95	0.602^*
Spacer with antibiotics
No	5	101	0.264^#
Yes	20	229
Time interval between prosthetic resection and hip revision (months)	6.87±2.49	7.02±3.17	0.291^*
CRP – C-reactive protein; ESR – erythrocyte sedimentation rate. ^* Mann-Whitney U test; ^# Chi-square test.

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Retrospective Study from a Single Center to Identify Risk Factors Associated with Reinfection in Patients Undergoing 2-Stage Revision Surgery for Periprosthetic Joint Infection

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