12 August 2022: Clinical Research
Clinical Value of Metagenomic Next-Generation Sequencing in Immunocompromised Patients with Sepsis
Zheng Cheng ABCDEFG , Feng Yu ABCDEFG*DOI: 10.12659/MSM.937041
Med Sci Monit 2022; 28:e937041
Table 1 Characteristics of cases.
| Clinical features | ICO | ICH | P value |
|---|---|---|---|
| Number of cases | 60 | 30 | NA |
| Sex, male | 38 | 15 | 0.226 |
| Age (mean±SD) | 57.35±19.49 | 53.56±16.30 | 0.363 |
| COPD | 4 | 3 | 0.889 |
| Hypertension | 25 | 11 | 0.648 |
| Diabetes | 12 | 7 | 0.715 |
| Chronic hepatic disease | 3 | 3 | 0.654 |
| Chronic renal disease | 5 | 6 | 0.211 |
| APACHE-II (mean±SD) | 18.43±5.97 | 21.76±5.10 | 0.011 |
| SOFA (mean±SD) | 9.90±3.60 | 10.66±3.66 | 0.346 |
| WBC (×10/L)* | 10.68 (7.91, 17.52) | 7.10 (3.38, 12.69) | 0.006 |
| Lymphocyte (×10/L)* | 7.08 (4.21, 8.81) | 7.31 (4.87, 19.69) | 0.168 |
| Platelet (×10/L)* | 125 (63.50, 178.25) | 65 (23.25, 133.25) | 0.035 |
| C-reactive protein (mg/L)* | 114.91 (69.18, 178.96) | 141.79 (31.61, 200) | 0.624 |
| Procalcitonin (ng/ml)* | 4.25 (0.70, 13.50) | 1.10 (0.43, 17.50) | 0.175 |
| HBP (ng/ml)* | 42.05 (12.65, 157.47) | 39.88 (9.55, 80.95) | 0.406 |
| Cholerythrin (μmol/L)* | 15.25 (12.12, 30.07) | 14.05 (9.40, 27.45) | 0.424 |
| ALT(U/L)* | 24.00 (15.00, 58.75) | 36.00 (21.75, 77.75) | 0.224 |
| AST(U/L)* | 36.50 (22.25, 97.75) | 64.50 (26.75, 102.50) | 0.071 |
| Urea nitrogen (mmol/L)* | 10.01 (6.19, 16.69) | 10.31 (7.86, 16.58) | 0.932 |
| SCr (μmol/L)* | 83.00 (55.12, 150.75) | 89.80 (48.47, 160.90) | 0.561 |
| Oxygenation index* | 252.50 (164.25, 312.25) | 206.00 (97.50, 268.0 | 0.087 |
| ICU length of stay (in days)* | 11.50 (7.00, 19.75) | 11.50 (5.00, 14.50) | 0.186 |
| Death | 29 | 24 | 0.004 |
| * Median (interquartile range). ALT – alanine aminotransferase; AST – aspartate aminotransferase; BALF :– bronchoalveolar lavage fluid; EICU – Emergency Intensive Care Unit; HBP – heparin-binding protein; ICH – immunocompromised; ICO – immunocompetent; NA – not applicable; NGS – next-generation sequencing; SCr – serum creatinine; SD – standard deviation; TDM – traditional detection methods; WBC – white blood cell counts. | |||