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09 July 2022: Meta-Analysis

Urodynamics in Early Diagnosis of Diabetic Bladder Dysfunction in Women: A Systematic Review and Meta-Analysis

Ágnes Rita Martonosi 123BCDEF , Piroska Pázmány 123BE , Szabolcs Kiss 123AD , Fanni Dembrovszky 3AF , Eduard Oštarijaš 3C , László Szabó 124ADG*

DOI: 10.12659/MSM.937166

Med Sci Monit 2022; 28:e937166

Table 1 Baseline characteristics of the included studies.

First authorCountry (centers) and recruitment periodStudy designInclusion criteriaLUTSNo. of patients with DC (%)No. of patients with peripheral neuropathy (%)
LUTS assessmentNo. of patients with LUTS (%)No. of patients with urge incontinence (%)No. of patients with stress incontinence (%)No. of patient with OAB (%)
Al Timimi et al 2020 []20 Iraq (single) 2018–2019Prospective cross-sectionalPatients with T2DM at least 5 years with LUTSNA71 (100%)3 (4.2%)3 (4.2%)13 (18.3%)31 (43.7%)NA
Changxiao et al 2014 []21 China (multi) 2010–2013Prospective cross-sectionalWomen aged ≥18 years with DMIUA/ICS1525 (93%)NANA918 (55.9%)1558 (95%)NA
Galí et al 2015 []22 Italy (single) 2008–2010NAPatients with T2DM at least 5 years with moderate/severe LUTSIPSS, QoL, OAB-q, ICI-SF19 (100%)14 (73.7%)4 (21%)15 (79%)NA14 (73.7%)
Golabek et al 2012 []23 Republic of Ireland (single) 2004–2008Retrospective cohortDiabetic female with OAB, defined as an involuntary rise in detrusor pressure of greater than 5 cm H2O during fillingNA29 (100%)15 (51%)029 (100%)29 (100%)NA
Lee et al 2007 []24 Taiwan (single) 2002–2003NAWomen with T2DM with no concurrent neurologic disorder or medical conditions that could interfere with voiding function, without bladder dysfunctionAUA-SI47 (100%)NANA047 (100%)# 18 (38.3%)
Løwenstein et al 2021 []25 Denmark (multi) 2016–2020Prospective randomizedAdult women with symptoms of urinary incontinence, urgency and nocturiaICIQ-UI SF, ICIQ-OAB31 (100%)NA4 (12.9%)4 (12.9%)NA4 (12.9%)
Malik et al 2020 []26 USA (multi) 2010–2014ProspectiveFemale patients with urology-based voiding dysfunction and no neurologic diseaseNA96 (100%)10 (11%)44 (45%)21 (24%)NANA
Shin et al 2016 []27 South-Korea (single) 2008–2015Retrospective cohortWomen without BOO who were diagnosed with SUINA92 (100%)092 (100%)0NANA
Tai et al 2009 []28 Taiwan (single) 2005–2007ProspectiveWomen with T2DM, age 50–75 yearsAUA-SI IUSS100 (36.7%)49 (18%)30 (11%)NANA52 (19.1%)
Yenilmez et al 2008 []29 Turkey (single) 2004–2007Prospective cross-sectionalPatients with T2DM and LUTSNA45 (100%)NANANA0* 17 (37.7%)
Ten full-text articles were included with a total of 2342 diabetic female patients from 9 countries. The majority of the patients (2055 – 87.7%) had LUTS; 1620 diabetic patients had urodynamic measurements and thus were included in the meta-analysis.
# Diabetic cystopathy was defined as postvoid residual volume greater than 100 mL.
* Diabetic cystopathy was defined as an increase in bladder capacity (more than 500 mL), impaired bladder sensation and decrease bladder contractility.
AUA-SI – American Urological Association Symptom Index; DC – diabetic cystopathy; DM – diabetes mellitus; ICIQ-OAB – International Consultation of Incontinence Questionnaire – Overactive bladder questionnaire; ICIQ-UI – International Consultation of Incontinence Questionnaire Urinary Incontinence Short Form; ICI-SF – International Consultation on Incontinence – Short form; IPSS – International Prostate Symptom Score; IUA/ICS: International Urogynecological Association/International Continence Society Standardization of Terminology Reports; IUSS – Indevus Urgency Severity Scale; LUTS – lower urinary tract symptoms; NA – not available data (not reported); OAB – overactive bladder (detrusor overactivity); OAB-q – Overactive Bladder Questionnaire; QoL – Quality of life Questionnaire; SUI – stress urinary incontinence; T2DM – type 2 diabetes mellitus.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750