09 July 2022: Meta-Analysis
Urodynamics in Early Diagnosis of Diabetic Bladder Dysfunction in Women: A Systematic Review and Meta-Analysis
Ágnes Rita Martonosi 123BCDEF , Piroska Pázmány 123BE , Szabolcs Kiss 123AD , Fanni Dembrovszky 3AF , Eduard Oštarijaš 3C , László Szabó 124ADG*DOI: 10.12659/MSM.937166
Med Sci Monit 2022; 28:e937166
Table 1 Baseline characteristics of the included studies.
| First author | Country (centers) and recruitment period | Study design | Inclusion criteria | LUTS | No. of patients with DC (%) | No. of patients with peripheral neuropathy (%) | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| LUTS assessment | No. of patients with LUTS (%) | No. of patients with urge incontinence (%) | No. of patients with stress incontinence (%) | No. of patient with OAB (%) | ||||||
| Al Timimi et al 2020 []20 | Iraq (single) 2018–2019 | Prospective cross-sectional | Patients with T2DM at least 5 years with LUTS | NA | 71 (100%) | 3 (4.2%) | 3 (4.2%) | 13 (18.3%) | 31 (43.7%) | NA |
| Changxiao et al 2014 []21 | China (multi) 2010–2013 | Prospective cross-sectional | Women aged ≥18 years with DM | IUA/ICS | 1525 (93%) | NA | NA | 918 (55.9%) | 1558 (95%) | NA |
| Galí et al 2015 []22 | Italy (single) 2008–2010 | NA | Patients with T2DM at least 5 years with moderate/severe LUTS | IPSS, QoL, OAB-q, ICI-SF | 19 (100%) | 14 (73.7%) | 4 (21%) | 15 (79%) | NA | 14 (73.7%) |
| Golabek et al 2012 []23 | Republic of Ireland (single) 2004–2008 | Retrospective cohort | Diabetic female with OAB, defined as an involuntary rise in detrusor pressure of greater than 5 cm H2O during filling | NA | 29 (100%) | 15 (51%) | 0 | 29 (100%) | 29 (100%) | NA |
| Lee et al 2007 []24 | Taiwan (single) 2002–2003 | NA | Women with T2DM with no concurrent neurologic disorder or medical conditions that could interfere with voiding function, without bladder dysfunction | AUA-SI | 47 (100%) | NA | NA | 0 | 47 (100%)# | 18 (38.3%) |
| Løwenstein et al 2021 []25 | Denmark (multi) 2016–2020 | Prospective randomized | Adult women with symptoms of urinary incontinence, urgency and nocturia | ICIQ-UI SF, ICIQ-OAB | 31 (100%) | NA | 4 (12.9%) | 4 (12.9%) | NA | 4 (12.9%) |
| Malik et al 2020 []26 | USA (multi) 2010–2014 | Prospective | Female patients with urology-based voiding dysfunction and no neurologic disease | NA | 96 (100%) | 10 (11%) | 44 (45%) | 21 (24%) | NA | NA |
| Shin et al 2016 []27 | South-Korea (single) 2008–2015 | Retrospective cohort | Women without BOO who were diagnosed with SUI | NA | 92 (100%) | 0 | 92 (100%) | 0 | NA | NA |
| Tai et al 2009 []28 | Taiwan (single) 2005–2007 | Prospective | Women with T2DM, age 50–75 years | AUA-SI IUSS | 100 (36.7%) | 49 (18%) | 30 (11%) | NA | NA | 52 (19.1%) |
| Yenilmez et al 2008 []29 | Turkey (single) 2004–2007 | Prospective cross-sectional | Patients with T2DM and LUTS | NA | 45 (100%) | NA | NA | NA | 0* | 17 (37.7%) |
| Ten full-text articles were included with a total of 2342 diabetic female patients from 9 countries. The majority of the patients (2055 – 87.7%) had LUTS; 1620 diabetic patients had urodynamic measurements and thus were included in the meta-analysis. # Diabetic cystopathy was defined as postvoid residual volume greater than 100 mL. * Diabetic cystopathy was defined as an increase in bladder capacity (more than 500 mL), impaired bladder sensation and decrease bladder contractility. AUA-SI – American Urological Association Symptom Index; DC – diabetic cystopathy; DM – diabetes mellitus; ICIQ-OAB – International Consultation of Incontinence Questionnaire – Overactive bladder questionnaire; ICIQ-UI – International Consultation of Incontinence Questionnaire Urinary Incontinence Short Form; ICI-SF – International Consultation on Incontinence – Short form; IPSS – International Prostate Symptom Score; IUA/ICS: International Urogynecological Association/International Continence Society Standardization of Terminology Reports; IUSS – Indevus Urgency Severity Scale; LUTS – lower urinary tract symptoms; NA – not available data (not reported); OAB – overactive bladder (detrusor overactivity); OAB-q – Overactive Bladder Questionnaire; QoL – Quality of life Questionnaire; SUI – stress urinary incontinence; T2DM – type 2 diabetes mellitus. | ||||||||||