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04 June 2022: Editorial

Editorial: Acute Hepatitis of Unknown Origin in Children. Is Autoimmunity at Play?

Nahum Mendez-Sanchez 12* , Shreya C. Pal 1

DOI: 10.12659/MSM.937371

Med Sci Monit 2022; 28:e937371

Table 1 The main clinical characteristics, patient presentation, biochemical and viral serology findings in children presenting with acute hepatitis of unknown origin.

Acute hepatitis in children of unknown cause
Clinical characteristicsBiochemical propertiesHistopathological findingsViral serologies
Jaundice (71.2%)Mild hepatocellular injuryNegative for Hepatitis A, B, C, D, and E
Vomiting (62.7%)Established criterion: serum transaminase >500 IU/L (AST or ALT)Massive hepatic necrosisAdenovirus F 41 (positive) – around 70%
Acholia (50.0%)Various degrees of hepatitis with no viral inclusionsCOVID-19 (positive) – around 18%
AT PRESENTATION: GI SYMPTOMSOther positive serologies:
Diarrhea (44.9%)
Nausea (30.5%)
Others: fatigue, choluria, anorexia, abdominal pain
AST – alanine aminotransferase; ALT – aspartate aminotransferase.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750