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15 March 2023: Clinical Research

Alterations in Amygdala/Hippocampal Volume Ratios in Children with Obstructive Sleep Apnea Syndrome Caused by Adenotonsillar Hypertrophy

Yanshan Ma 1ABCE* , Zheli Niu 2ABCE* , Lin Ruan 2CDF , Sisi Xue 3CDF , Nan Li 3F , Xiaoguang Yao 3ABCE* , Qiang Li 3AEFG*

DOI: 10.12659/MSM.937420

Med Sci Monit 2023; 29:e937420

Table 1 Demographic characteristics and clinical variables of subjects.

CategoryATH/OSA (n=100)Controls (n=100)P value
Age (y)Mean (95% CI)5. 74 (5.14, 6.35)5.95 (5.35, 6.55)0.57
BMI z scoreMean (95% CI)0.37 (0.23, 0.52)0.32 (0.19, 0.45)0.57
Smoking status in familyy/n93/790/100.31
Chronic or allergic rhinitisy/n14/860/1000.000
Food/drug allergyy/n7/935/950.552
Eosinophil count (μL)289.15±67.10279.12±51.640.237
Total serum IgE (U/mL)251.27±63.21236.42±66.950.108
Amygdala volumecm2.65±0.212.17±0.180.000
Hippocampus volumecm7.08±0.117.29±0.150.000
A/H ratio0.37±0.030.30±0.020.000
Tonsil hypertrophy
 I°N (%)19 (19%)
 II°N (%)68 (68%)
 III°N (%)13 (13%)
Adenoid hypertrophy
 I°N (%)5 (5%)
 II°N (%)30 (30%)
 III°N (%)58 (58%)
 IV°N (%)7 (7%)
A/N ratioMean (95% CI)0.85 (0.83, 0.86)0.56 (0.55, 0.57)0.000
Disease duration(months)Mean (95% CI)3.25 (2.96, 3.54)
Polysomnography variables
Mean SaO2(%)95.33±2.41
min Sao2(%)74.87±12.62
Percentage of SaO2(%)10.24±8.79
The data of the clinical variables and demographic characteristics are expressed as the mean±standard deviation (SD) for continuous variables when the data were normally distributed, as a 95% confidence interval (CI) when the data had a skewed distribution, or counts (percentages) for discrete variables.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750