08 August 2022: Clinical Research
Identification of Hepatic Dendritic Cells in Liver Biopsies in Patients with Metabolic Dysfunction-Associated Fatty Liver Diseas (MAFLD) and Obesity
Beatriz Barranco-Fragoso 12ABC , Shreya C. Pal 34CDEFG , Luis E. Díaz-Orozco 34ABCDEF , Rita Dorantes-Heredia 5BCD , Xingshun Qi 6F , Nahum Méndez-Sánchez 34ACDEF*DOI: 10.12659/MSM.937528
Med Sci Monit 2022; 28:e937528
Table 4 Hepatic dendritic cells’ expression in MAFLD according to patients’ BMI and either the presence or absence of fibrosis:The data show the difference in dendritic cell expression among different weight groups; the most outstanding is the difference between CD11c+ cell expression in morbidly obese individuals compared to lower degrees in obese and non-obese individuals.
| Study variablesPatients with MAFLD (n=128) | CD11c+ cellsYes (n=72)N (%) | CD11c+ cellsNo (n=56) N (%) | Odds ratio (OR) | Statistical test (chi square or χ2)significance level (P value*) |
|---|---|---|---|---|
| Morbid obesity | 49 (68.06) | 27 (48.21) | 1.51 (0.65–3.49) | χ=0.9576 |
| Obesity GI–II | 18 (25) | 15 (26.79) | p=0.327 | |
| Morbid obesity | 49 (68.06) | 27 (48.21) | 5.08 (1.65–15.6) | χ=9.0216 |
| Non-obese | 5 (6.94) | 14 (25) | P=0.0027 | |
| Obesity GI–II | 18 (25) | 15 (26.79) | 3.36 (0.98–11.49) | χ=3.895 |
| Non-obese | 5 (6.94) | 14 (25) | p=0.048 | |
| Fibrosis | 33 (45.83) | 31 (55.36) | 0.68 (0.33–1.37) | χ=1.1429 |
| No fibrosis | 39 (54.17) | 25 (44.64) | P=0.285 | |
| Morbid obese with fibrosis | 20 (27.78) | 12 (21.43) | 1.66 (0.53–5.16) | χ=0.7879 |
| Obese grade I–II with fibrosis | 10 (13.88) | 10 (17.86) | P=0.3747 | |
| Morbid obese with fibrosis | 20 (27.78) | 12 (21.43) | 5 (1.12–22.18) | χ=4.919 |
| Non-obese with fibrosis | 3 (4.17) | 9 (16.07) | P=0.0266 | |
| Obese grade I–II with fibrosis | 10 (13.88) | 10 (17.86) | 3 (0.62–14.46) | χ=1.943 |
| Non-obese with fibrosis | 3 (4.17) | 9 (16.07) | P=0.1633 | |
| BMI – body mass index; MAFLD – metabolic (dysfunction)-associated fatty liver disease. * We considered significant differences as those with a 2-sided value of | ||||