05 September 2022: Clinical Research
Interaction of High-Sugar Diet and History of Stroke with Risk of Cognitive Decline in Older Adults
Qian Xu 1AEFG , Sicong Zhang 2BCD , Yanqing Gu 1C , Ping Wang 1D , Qian Zhang 1B , Chunlei Shan 234AEG*DOI: 10.12659/MSM.937572
Med Sci Monit 2022; 28:e937572
Supplementary Table 1 Interaction between a history of stroke and high-sugar diet in affecting cognitive decline in people with different education levels.
| Content of added sugar | History of stroke | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | ||
| Normal | No | Ref | Ref | Ref | |||
| Normal | Yes | 0.984 (0.293–3.305) | 0.979 | 0.875 (0.295–2.594) | 0.228 | 0.744 (0.156–3.543) | 0.702 |
| High | No | 1.558 (0.944–2.573) | 0.081 | 1.537 (0.925–2.551) | 0.803 | 1.434 (0.846–2.429) | 0.173 |
| High | Yes | 1.337 (0.392–4.560) | 0.632 | 1.420 (0.385–5.237) | 0.094 | 1.051 (0.311–3.551) | 0.935 |
| RERI | −0.206 (−2.577–2.166) | 0.008 (−2.364–2.381) | −0.128 (−1.989–1.734) | ||||
| AP | −0.154 (−2.068–1.760) | 0.006 (−1.659–1.671) | −0.121 (−1.985–1.742) | ||||
| S | 0.621 (0.002–1.000) | 1.020 (0.003–1.000) | 0.284 (0.001–1.000) | ||||
| Normal | No | ||||||
| Normal | Yes | 1.849 (0.607–5.634) | 0.269 | 1.398 (0.566–3.451) | 0.455 | 1.585 (0.671–3.747) | 0.283 |
| High | No | 1.052 (0.754–1.467 | 0.758 | 1.481 (1.068–2.052) | 0.020 | 1.430 (0.981–2.084) | 0.062 |
| High | Yes | 9.868 (1.791–54.369) | 0.010 | 15.281 (2.689–86.838) | 0.003 | 26.199 (2.169–346.516) | 0.012 |
| RERI | 7.967 (−7.936–23.869) | 13.402 (−11.901–38.705) | – | ||||
| AP | 0.807 (0.469–1.145) | 0.877 (0.671–1.083) | |||||
| S | 9.838 (0.767–126.116) | 16.251 (2.037–129.679) | |||||
| Normal | No | ||||||
| Normal | Yes | 3.196 (1.732–5.895) | 2.682 (1.456–4.941) | 0.002 | 2.233 (1.159–4.299) | 0.018 | |
| High | No | 1.924 (1.125–3.291) | 0.018 | 1.840 (1.056–3.206) | 0.033 | 1.553 (0.849–2.840) | 0.147 |
| High | Yes | 5.038 (1.542–16.459) | 0.009 | 4.540 (1.348–15.288) | 0.016 | 2.029 (0.580–7.096) | 0.258 |
| RERI | 0.918 (−4.043–5.880) | 1.018 (−3.939–5.974) | −1.097 (−2.808–0.615) | ||||
| AP | 0.182 (−0.615–0.980) | 0.224 (−0.632–1.080) | −0.847 (−2.899–1.205) | ||||
| S | 1.294 (0.384–4.367) | 1.403 (0.337–5.843) | 0.212 (0.002–29.428) | ||||