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19 September 2022: Clinical Research

Circulating Methylated DNA Analyses to Predict Recurrence Risk and Adjuvant Chemotherapy Benefit in Stage II to III Colorectal Cancer

Zhen Yuan 12ABCEF* , Shuyuan Wang 12ABCDEF* , Kemin Ni 12ACDF* , Yixiang Zhan 12ACDF* , Hong Ma 1BDF , Xinyu Liu 13ABC , Ran Xin 2ABC , Xingyu Zhou 2BC , Zhaoce Liu 12BC , Xuanzhu Zhao 14BC , Xin Yin 2BC , Hangyu Ping 2BC , Yaohong Liu 2BC , Wanting Wang 4BC , Suying Yan 4BC , Qiurong Han 4BC , Wei Cui 5CD , Xipeng Zhang 167ADF , Qinghuai Zhang 167ABCD* , Chunze Zhang 167ABCDEFG*

DOI: 10.12659/MSM.937757

Med Sci Monit 2022; 28:e937757

Supplementary Table 1 Baseline characteristics of patients with stage II–III CRC after propensity matching.

VariablesPreoperative mSEPT9 after matching at 1: 1Postoperative mSEPT9 after matching at 1: 4Longitudinal mSETP9 after matching at 1: 2
Positive (n=149)Negative (n=149)pPositive (n=59)Negative (n=190)pPositive (n=105)Negative (n=191)p
 ≤60 years69 (46.3)67 (45.0)0.90721 (35.6)76 (40.0)0.64736 (34.3)73 (38.2)0.531
 >60 years80 (53.7)82 (55.0)38 (64.4)114 (60)69 (65.7)118 (61.8)
 Female72 (41.6)60 (40.3)1.00025 (42.4)79 (41.6)1.00038 (36.2)71 (37.2)0.216
 Male101 (58.4)89 (59.7)34 (57.6)111 (58.4)67 (63.8)120 (62.8)
 Well/moderate98 (65.8)99 (66.4)1.00031 (52.5)118 (62.1)0.22461 (58.1)118 (61.8)0.537
 Poor51 (34.2)50 (33.6)28 (47.5)72 (37.9)44 (41.9)73 (38.2)
 Adenocarcinoma140 (94.0)140 (94.0)1.00052 (88.1)173 (91.1)0.61395 (90.5)174 (91.1)0.836
 Other types9 (6.0)9 (6.0)7 (11.9)17 (8.9)10 (9.5)17 (8.9)
 II69 (46.3)70 (47.0)1.00018 (30.5)70 (36.8)0.43736 (34.3)63 (33.0)0.898
 III80 (53.7)79 (53.0)41 (69.5)120 (63.2)69 (65.7)128 (67.0)
 pT1/23 (2.0)3 (2.0)1.0003 (5.1)11 (5.8)1.0005 (4.8)8 (4.2)0.776
 pT3/4146 (98.0)146 (98.0)56 (94.9)179 (94.2)100 (95.2)183 (95.8)
 pN069 (46.3)70 (47.0)1.00018 (30.5)70 (36.8)0.43736 (34.3)63 (33)0.898
 pN1/280 (53.7)79 (53.0)41 (69.5)120 (63.2)69 (65.7)128 (67)
 Rectum86 (49.7)75 (50.3)0.80231 (52.5)93 (48.9)0.79856 (53.3)94 (49.2)0.758
 Left colon54 (31.2)40 (26.8)13 (22)50 (26.3)29 (27.6)60 (31.4)
 Right colon33 (19.1)34 (22.8)15 (25.4)47 (24.7)20 (19)37 (19.4)
 Yes18 (12.1)15 (10.1)0.71221 (35.6)12 (6.3)34 (32.4)10 (5.2)
 No131 (87.9)134 (89.9)38 (64.4)178 (93.7)71 (67.6)181 (94.8)
CRC – colorectal cancer; mSEPT9 – methylated setpin9; ACT – Adjuvant chemotherapy.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750