14 September 2022 : Clinical Research
C-Reactive Protein/Albumin Ratio at Diagnosis of Pediatric Inflammatory Bowel Disease: A Retrospective Multi-Center Study
Aleksandra Glapa-Nowak
1ABCDEF, Mariusz Szczepanik 1ABE, Aleksandra Banaszkiewicz 2BE, Jarosław Kwiecień 3BE, Anna Szaflarska-Popławska4BE, Urszula Grzybowska-Chlebowczyk 5BE, Marcin Osiecki 6BE, Jarosław Kierkuś 6BE, Marcin Dziekiewicz 2BE, Jarosław Walkowiak 1ACDEFG*
DOI: 10.12659/MSM.937842
Med Sci Monit 2022; 28:e937842
Table 1 Basic characteristics of subjects (n=345).
| Variables Median (IQR) or n (%) | CD | UC | p value |
|---|---|---|---|
| At inclusion | 15 (13–17) | 15 (11–16) | 0.012 |
| At diagnosis | 12 (10–14) | 12 (8–15) | 0.237 |
| 1.7 (0.6–3.9) | 1.5 (0.2–3.5) | 0.166 | |
| Weight at diagnosis [z score] | −0.81 ([−1.39]–[−0.00]) | −0.54 ([−1.23]−0.17) | 0.025 |
| Height at diagnosis [z score] | −0.37 ([−1.33]−0.48) | 0.02 ([−0.75]−0.75) | 0.005 |
| Body mass index at diagnosis [z score] | −0.77 ([−1.46]–[−0.06]) | −0.54 ([−1.08]−0.15) | 0.043 |
| Albumin at diagnosis [g/dl] | 3.9 (3.5–4.3) | 4.1 (3.7–4.4) | 0.003 |
| Albumin at worst flare [g/dl] | 3.9 (3.5–4.3) | 4.2 (3.8–4.4) | <0.001 |
| CRP at diagnosis [mg/L] | 13.0 (2.1–30.3) | 2.4 (0.5–11.5) | <0.001 |
| CRP at worst flare [mg/L] | 14.3 (3.3–39.1) | 2.7 (0.6–15.0) | <0.001 |
| CRP/albumin ratio at diagnosis [mg/g] | 0.34 (0.05–0.90) | 0.06 (0.01–0.28) | <0.001 |
| CRP/albumin ratio at worst flare [mg/g] | 0.38 (0.08–1.03) | 0.07 (0.01–0.34) | <0.001 |
| PUCAI at diagnosis | 45 (30–60) | ||
| PUCAI at worst flare | 50 (35–65) | ||
| PCDAI at diagnosis | 32 (23–48) | ||
| PCDAI at worst flare | 39 (30–53) | ||
| Systemic corticosteroids* | 94 (50.5) | 113 (71.1) | <0.001 |
| Immunosuppressive and anti-inflammatory treatment** | 144 (77.4) | 89 (56.3) | <0.001 |
| Biological therapy*** | 90 (48.4) | 39 (24.5) | <0.001 |
| Operative treatment | 23 (12.4) | 3 (1.9) | <0.001 |
| Colectomy | 2 (1.1) | 3 (1.9) | 0.666 |
| Resection | 9 (4.8) | 0 (0.0) | 0.004 |
| Fistula | 4 (2.2) | 0 (0.0) | 0.127 |
| Perforation | 2 (1.1) | 0 (0.0) | 0.501 |
| Abscess | 6 (3.2) | 0 (0.0) | 0.033 |
| * e.g. methylprednisolone, prednisone, hydrocortisone; ** e.g. azathioprine, methotrexate, mercaptopurine, cyclosporine, mycophenolate mofetil, tacrolimus; *** e.g. infliximab, adalimumab, golimumab, vedolizumab. CD – Crohn’s disease; CRP – C-reactive protein (reference values 0–5 mg/L); IQR – interquartile range; PUCAI – Pediatric Ulcerative Colitis Activity Index; PCDAI – Pediatric Crohn’s Disease Activity Index; UC – ulcerative colitis. | |||