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14 October 2022: Clinical Research

Correlation Between Trough Level of Abiraterone and Prostate-Specific Antigen (PSA) Response in Metastatic Hormone-Sensitive Prostate Cancer

Zin W. Myint 12ABCDEFG* , Jill M. Kolesar 23CDE , Joseph Robert McCorkle 2CDE , Jianrong Wu 4C , Carleton S. Ellis 23CDE , Danielle E. Otto 23CDE , Peng Wang 12ACDE

DOI: 10.12659/MSM.938091

Med Sci Monit 2022; 28:e938091

Table 2 Summary of abiraterone trough concentration levels, prostate-specific antigen levels, germline HSD3B1, and survival data of all patients.

1 Month3 Months7 MonthsStatusgRisk allele copy
2132.53.075.510.5520.930.02Refused35.8Homo (A/A)0CRAlive
3246.01.657.890.2312.501.2526.8631.7Hetero (C/A)1SDAlive
41536.07.444.551.667.090.413.5832Homo (A/A)0PRAlive
5735.63.78240.461.9518.220.8421.3731.5Homo (A/A)0PRAlive
673.563.069.010.2516.280.0814.6823.5Homo (A/A)0PRAlive
7150.2183.3611.902.915.864.6035Hetero (C/A)1PRAlive
8620.384.360.247.480.2010.0938.7Hetero (C/A)1PRAlive
91160165.4012.2549.206.52----20.8Homo (A/A)0DPDead
11121.76.9221.630.4225.480.0422.9428.3Hetero (C/A)1SDAlive
121225.8681.820.2729.960.0321.8031.4Homo (A/A)0SDAlive
13681.9217.250.654.84----27.2Hetero (C/A)1DPDead
a bPSA, PSA at diagnosis;
b ng/mL;
c BMI, body mass index;
d allele 1245, rs1047303 (A=/C=);
e DD, disease status;
F SS, survival status;
g homo (alleles) and hetero (alleles);
CR – complete response; S – stable disease; PR – partial response; DP – disease progression. Bolded values are from patients that required dose-reduction after they went off the study.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750