Correlation Between Trough Level of Abiraterone and Prostate-Specific Antigen (PSA) Response in Metastatic Hormone-Sensitive Prostate Cancer

Zin W. Myint; Jill M. Kolesar; Joseph Robert McCorkle; Jianrong Wu; Carleton S. Ellis; Danielle E. Otto; Peng Wang

doi:10.12659/MSM.938091

14 October 2022 : Clinical Research

Correlation Between Trough Level of Abiraterone and Prostate-Specific Antigen (PSA) Response in Metastatic Hormone-Sensitive Prostate Cancer

Zin W. Myint^12ABCDEFG*, Jill M. Kolesar^23CDE, Joseph Robert McCorkle^2CDE, Jianrong Wu^4C, Carleton S. Ellis^32CDE, Danielle E. Otto^23CDE, Peng Wang^12ACDE

DOI: 10.12659/MSM.938091

Med Sci Monit 2022; 28:e938091

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Table 4 Correlation between 1-month, 3-month, and 7-month abiraterone trough levels and prostate-specific antigen levels stratified by obesity vs non-obesity.

Correlation (PSA, AA)	Spearman rank correlation	P value	Spearman correlation	P value
Correlation (PSA, AA)	Obese (BMI >30)		Non-obese (BMI <30)
1 Month	0.2	0.7	0.2000	0.75
3 Months	−0.7	0.19	−0.6000	0.40
7 Months	−0.00	1.0	–
BMI – body mass index, PSA – prostate-specific antigen; AA – abiraterone acetate.

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Correlation Between Trough Level of Abiraterone and Prostate-Specific Antigen (PSA) Response in Metastatic Hormone-Sensitive Prostate Cancer

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