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14 October 2022: Clinical Research

Correlation Between Trough Level of Abiraterone and Prostate-Specific Antigen (PSA) Response in Metastatic Hormone-Sensitive Prostate Cancer

Zin W. Myint 12ABCDEFG* , Jill M. Kolesar 23CDE , Joseph Robert McCorkle 2CDE , Jianrong Wu 4C , Carleton S. Ellis 23CDE , Danielle E. Otto 23CDE , Peng Wang 12ACDE

DOI: 10.12659/MSM.938091

Med Sci Monit 2022; 28:e938091

Table 7 Association between HSD3B1 genotype risk allele and 1-month, 3-month, and 7-month abiraterone trough levels.

HSD3B1 genotypeNMean (tABI)aP value
1 Month
0b 47.830.398
1c 611.07
3 Months
0b 412.710.678
1c 510.64
7 Months
0b 29.130.386
1c 416.12
a tABI, trough abiraterone;
b homozygous (A/A) genotype;
c heterozygous (C/A) genotype;
HSD3B1, hydroxyl-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750